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@misc{1339427,
author = {Štourač, Jan and Bendl, Jaroslav and Šebestová, Eva and Vávra, Ondřej and Musil, Miloš and Brezovský, Jan and Damborský, Jiří},
keywords = {protein engineering; smart library design; computational mutagenesis; hotspot prediction},
language = {eng},
institution = {MU},
organization = {MU},
title = {HotSpot Wizard 2.0},
url = {http://loschmidt.chemi.muni.cz/hotspotwizard2/},
year = {2015}
}
TY -
ID - 1339427
AU - Štourač, Jan - Bendl, Jaroslav - Šebestová, Eva - Vávra, Ondřej - Musil, Miloš - Brezovský, Jan - Damborský, Jiří
PY - 2015
TI - HotSpot Wizard 2.0
KW - protein engineering
KW - smart library design
KW - computational mutagenesis
KW - hotspot prediction
UR - http://loschmidt.chemi.muni.cz/hotspotwizard2/
L2 - http://loschmidt.chemi.muni.cz/hotspotwizard2/
N2 - HotSpot Wizard is a web server for automatic identification of hot spots for engineering of substrate specificity, activity or entantioselectivity of enzymes and for annotation of protein structures. HSW 2.0 integrates 3 databases and 18 computational tools, including our in-house tool for analysis of protein tunnels and channels Caver 3.0. In the output, users can explore hot spots based on 4 protein engineering strategies: (i) functional hot spots represented by highly mutable residues located in the active site pocket or access tunnels, (ii) stability hot spots represented by flexible residues, (iii) stability hot spots identified by back-to-consensus approach, and (iv) correlated hot spots represented by pairs of coevolving residues that modulate enzyme activity and selectivity.
ER -
ŠTOURAČ, Jan, Jaroslav BENDL, Eva ŠEBESTOVÁ, Ondřej VÁVRA, Miloš MUSIL, Jan BREZOVSKÝ a Jiří DAMBORSKÝ. \textit{HotSpot Wizard 2.0}. 2015.
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