VIJAI, Joseph, Zhaoming WANG, Sonja I. BERNDT, Christine F. SKIBOLA, Susan L. SLAGER, Silvia de SANJOSE, Mads MELBYE, Benght GLIMELIUS, Paige M. BRACCI, Lucia CONDE, Brenda M. BIRMANN, Sophia S. WANG, Angela R. BROOKS-WILSON, Qing LAN, Paul I.W. BAKKER, Roel C.H. VERMEULEN, Carol PORTLOCK, Stephen M. ANSELL, Brian K. LINK, Jacques RIBY, Kari E. NORTH, Jian GU, Henrik HJALGRIM, Wendy COZEN, Nikolaus BECKER, Lauren R. TERAS, John J. SPINELLI, Jenny TURNER, YaweiW ZHANG, Mark P. PURDUE, Graham G. GILES, Rachel S. KELLY, Anne ZELENIUCH-JACQUOTTE, Maria Grazia ENNAS, Alain MONNEREAU, Kimberly A. BERTRAND, Demetrius ALBANES, Tracy LIGHTFOOT, Meredith YEAGER, Charles C. CHUNG, Laurie BURDETT, Amy HUTCHINSON, Charles LAWRENCE, Rebecca MONTALVAN, Liming LIANG, Jinyan HUANG, Baoshan MA, Danylo J. VILLANO, Ann MARIA, Marina CORINES, Tinu THOMAS, Anne J. NOVAK, Ahmet DOGAN, Mark LIEBOW, Carrie A. THOMPSON, Thomas E. WITZIG, Thomas M. HABERMANN, George J. WEINER, Martyn T. SMITH, Elizabeth HOLLY, Rebecca D. JACKSON, Lesley F. TINKER, Yuanging YE, Hans-Olov ADAMI, Karin E. SMEDBY, Anneclaire DE ROOS, Patricia HARTGE, Lindsay M. MORTON, Richard K. SEVERSON, Yolanda BENAVENTE, Paolo BOFFETTA, Paul BRENNAN, Lenka FORETOVÁ, Marc MAYNADIE, James MCKAY, Anthony STAINES, W. Ryan DIVER, Claire M. VAJDIC, Bruce K. ARMSTRONG, Anne KRICKER, TongzhangZ ZHENG, Theodore R. HOLFORD, Gianluca SEVERI, Paolo VINEIS, Giovanni M. FERRI, Rosalia RICCO, Lucia MILIGI, Jacqueline CLAVEL, Edward GIOVANNUCCI, Peter KRAFT, Jarmo VIRTAMO, Alex SMITH, Eleanor KANE, Eve ROMAN, Brian C.H. CHIU, Joseph F. FRAUMENI, Xifeng WU, James R. CERHAN, Kenneth OFFIT, Stephen J. CHANOCK, Nathaniel ROTHMAN and Alexandra NIETERS. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature Communications. London: Nature Publishing Group, 2015, vol. 6, UNSP 5751, p. 1-7. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/ncomms6751.
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Basic information
Original name A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Authors VIJAI, Joseph (840 United States of America), Zhaoming WANG (840 United States of America), Sonja I. BERNDT (840 United States of America), Christine F. SKIBOLA (840 United States of America), Susan L. SLAGER (840 United States of America), Silvia de SANJOSE (724 Spain), Mads MELBYE (840 United States of America), Benght GLIMELIUS (840 United States of America), Paige M. BRACCI (840 United States of America), Lucia CONDE (840 United States of America), Brenda M. BIRMANN (840 United States of America), Sophia S. WANG (840 United States of America), Angela R. BROOKS-WILSON (124 Canada), Qing LAN (840 United States of America), Paul I.W. BAKKER (528 Netherlands), Roel C.H. VERMEULEN (528 Netherlands), Carol PORTLOCK (840 United States of America), Stephen M. ANSELL (840 United States of America), Brian K. LINK (840 United States of America), Jacques RIBY (840 United States of America), Kari E. NORTH (840 United States of America), Jian GU (840 United States of America), Henrik HJALGRIM (208 Denmark), Wendy COZEN (840 United States of America), Nikolaus BECKER (276 Germany), Lauren R. TERAS (840 United States of America), John J. SPINELLI (124 Canada), Jenny TURNER (36 Australia), YaweiW ZHANG (840 United States of America), Mark P. PURDUE (840 United States of America), Graham G. GILES (36 Australia), Rachel S. KELLY (826 United Kingdom of Great Britain and Northern Ireland), Anne ZELENIUCH-JACQUOTTE (840 United States of America), Maria Grazia ENNAS (380 Italy), Alain MONNEREAU (250 France), Kimberly A. BERTRAND (840 United States of America), Demetrius ALBANES (840 United States of America), Tracy LIGHTFOOT (826 United Kingdom of Great Britain and Northern Ireland), Meredith YEAGER (840 United States of America), Charles C. CHUNG (840 United States of America), Laurie BURDETT (840 United States of America), Amy HUTCHINSON (840 United States of America), Charles LAWRENCE (840 United States of America), Rebecca MONTALVAN (840 United States of America), Liming LIANG (840 United States of America), Jinyan HUANG (840 United States of America), Baoshan MA (840 United States of America), Danylo J. VILLANO (840 United States of America), Ann MARIA (840 United States of America), Marina CORINES (840 United States of America), Tinu THOMAS (840 United States of America), Anne J. NOVAK (840 United States of America), Ahmet DOGAN (840 United States of America), Mark LIEBOW (840 United States of America), Carrie A. THOMPSON (840 United States of America), Thomas E. WITZIG (840 United States of America), Thomas M. HABERMANN (840 United States of America), George J. WEINER (840 United States of America), Martyn T. SMITH (840 United States of America), Elizabeth HOLLY (840 United States of America), Rebecca D. JACKSON (840 United States of America), Lesley F. TINKER (840 United States of America), Yuanging YE (840 United States of America), Hans-Olov ADAMI (840 United States of America), Karin E. SMEDBY (752 Sweden), Anneclaire DE ROOS (840 United States of America), Patricia HARTGE (840 United States of America), Lindsay M. MORTON (840 United States of America), Richard K. SEVERSON (840 United States of America), Yolanda BENAVENTE (724 Spain), Paolo BOFFETTA (840 United States of America), Paul BRENNAN (250 France), Lenka FORETOVÁ (203 Czech Republic, guarantor, belonging to the institution), Marc MAYNADIE (250 France), James MCKAY (250 France), Anthony STAINES (372 Ireland), W. Ryan DIVER (276 Germany), Claire M. VAJDIC (36 Australia), Bruce K. ARMSTRONG (36 Australia), Anne KRICKER (36 Australia), TongzhangZ ZHENG (840 United States of America), Theodore R. HOLFORD (840 United States of America), Gianluca SEVERI (380 Italy), Paolo VINEIS (380 Italy), Giovanni M. FERRI (380 Italy), Rosalia RICCO (380 Italy), Lucia MILIGI (380 Italy), Jacqueline CLAVEL (380 Italy), Edward GIOVANNUCCI (840 United States of America), Peter KRAFT (840 United States of America), Jarmo VIRTAMO (246 Finland), Alex SMITH (826 United Kingdom of Great Britain and Northern Ireland), Eleanor KANE (826 United Kingdom of Great Britain and Northern Ireland), Eve ROMAN (826 United Kingdom of Great Britain and Northern Ireland), Brian C.H. CHIU (840 United States of America), Joseph F. FRAUMENI (840 United States of America), Xifeng WU (840 United States of America), James R. CERHAN (840 United States of America), Kenneth OFFIT (840 United States of America), Stephen J. CHANOCK (840 United States of America), Nathaniel ROTHMAN (840 United States of America) and Alexandra NIETERS (276 Germany).
Edition Nature Communications, London, Nature Publishing Group, 2015, 2041-1723.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 11.329
RIV identification code RIV/00216224:14110/15:00087037
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1038/ncomms6751
UT WoS 000348646500001
Keywords in English Marginal zone lymphoma; non-Hodgkin lymphoma
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 18/3/2016 15:46.
Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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