Thermodynamic, Kinetic and Structural  Study of Transition
Metal Complexes of NOTA ligand

D 2015

Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand

ŠEVČÍKOVÁ, Romana, Jakub VANĚK, Přemysl LUBAL, Vojtěch KUBÍČEK, Zuzana BÖHMOVÁ et. al.

Basic information

Original name

Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand

Authors

ŠEVČÍKOVÁ, Romana (203 Czech Republic, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution), Přemysl LUBAL (203 Czech Republic, guarantor, belonging to the institution), Vojtěch KUBÍČEK (203 Czech Republic), Zuzana BÖHMOVÁ (203 Czech Republic), Jan KOTEK (203 Czech Republic, belonging to the institution) and Petr HERMANN (203 Czech Republic, belonging to the institution)

Edition

Wroclaw, Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015), p. 47-48, 2 pp. 2015

Publisher

University of Wroclaw

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10402 Inorganic and nuclear chemistry

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

RIV identification code

RIV/00216224:14310/15:00081669

Organization unit

Faculty of Science

ISSN

Keywords in English

Cu(II) ion; NOTA macrocyclic ligand

Abstract

V originále

Triaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2]. Among them, copper radioisotopes are promising for application in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h) [1,2]. Cu(II) ion should be bound in the form of metal complexes of high thermodynamic stability and kinetic inertness, which are required for the use in vivo for medical purposes. One of the most frequently used triaaza-macrocyclic ligand is H3nota (1,4,7-triazacyclononane-1,4,7-triacetic acid). Despite that, broad range of basic data regarding structural and some thermodynamic properties and kinetic behavior of its complexes has not been reported. Scheme: Formula of 1,4,7-triazacyclononane-1,4,7-triacetic acid (H3nota) Here, we report on protonation constants as well as stability constants of metal complexes (Cu(II), Zn(II), Ni(II), Co(II), Cd(II), Pb(II), Ca(II), Mg(II)) which show that the ligand cavity is too small for large metal ions and, therefore, the stability constants are significantly decreasing. This observation was confirmed for molecular structure of [Pb(nota)]– complex found in the solid state. The kinetic studies show the fast formation and slow dissociation of copper(II) complexes and, therefore, this ligand is suitable for sequestering of copper radioisotopes utilized in nuclear medicine. The results are compared with rate constants obtained for open-chain ligands, e.g. EDTA, or other triazamacrocyclic ligands without pendant arms.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GA13-08336S, research and development project

Name: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Investor: Czech Science Foundation

Citovat

ŠEVČÍKOVÁ, Romana, Jakub VANĚK, Přemysl LUBAL, Vojtěch KUBÍČEK, Zuzana BÖHMOVÁ, Jan KOTEK and Petr HERMANN. Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand. In Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015). Wroclaw: University of Wroclaw, 2015, p. 47-48. ISSN 2239-2459.

@inproceedings{1340830,
   author = {Ševčíková, Romana and Vaněk, Jakub and Lubal, Přemysl and Kubíček, Vojtěch and Böhmová, Zuzana and Kotek, Jan and Hermann, Petr},
   address = {Wroclaw},
   booktitle = {Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015)},
   keywords = {Cu(II) ion; NOTA macrocyclic ligand},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Wroclaw},
   pages = {47-48},
   publisher = {University of Wroclaw},
   title = {Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand},
   year = {2015}
}

TY  - JOUR
ID  - 1340830
AU  - Ševčíková, Romana - Vaněk, Jakub - Lubal, Přemysl - Kubíček, Vojtěch - Böhmová, Zuzana - Kotek, Jan - Hermann, Petr
PY  - 2015
TI  - Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand
PB  - University of Wroclaw
CY  - Wroclaw
KW  - Cu(II) ion
KW  - NOTA macrocyclic ligand
N2  - Triaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2]. Among them, copper radioisotopes are promising for application in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h) [1,2]. Cu(II) ion should be bound in the form of metal complexes of high thermodynamic stability and kinetic inertness, which are required for the use in vivo for medical purposes. One of the most frequently used triaaza-macrocyclic ligand is H3nota (1,4,7-triazacyclononane-1,4,7-triacetic acid). Despite that, broad range of basic data regarding structural and some thermodynamic properties and kinetic behavior of its complexes has not been reported. Scheme: Formula of 1,4,7-triazacyclononane-1,4,7-triacetic acid (H3nota) Here, we report on protonation constants as well as stability constants of metal complexes (Cu(II), Zn(II), Ni(II), Co(II), Cd(II), Pb(II), Ca(II), Mg(II)) which show that the ligand cavity is too small for large metal ions and, therefore, the stability constants are significantly decreasing. This observation was confirmed for molecular structure of [Pb(nota)]– complex found in the solid state. The kinetic studies show the fast formation and slow dissociation of copper(II) complexes and, therefore, this ligand is suitable for sequestering of copper radioisotopes utilized in nuclear medicine. The results are compared with rate constants obtained for open-chain ligands, e.g. EDTA, or other triazamacrocyclic ligands without pendant arms.
ER  -

ŠEVČÍKOVÁ, Romana, Jakub VANĚK, Přemysl LUBAL, Vojtěch KUBÍČEK, Zuzana BÖHMOVÁ, Jan KOTEK and Petr HERMANN. Thermodynamic, Kinetic and Structural Study of Transition Metal Complexes of NOTA ligand. In \textit{Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015)}. Wroclaw: University of Wroclaw, 2015, p.~47-48. ISSN~2239-2459.

Detailed Information on Publication Record