Effect of alkali metal ions on dissociation kinetics of Cu(II)
complexes of DOTP-like macrocyclic ligands

D 2015

Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands

MICHALICOVÁ, Romana, Přemysl LUBAL, Luis MP LIMA, Rita DELGADO, Petr HERMANN et. al.

Základní údaje

Originální název

Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands

Autoři

MICHALICOVÁ, Romana (203 Česká republika, domácí), Přemysl LUBAL (203 Česká republika, garant, domácí), Luis MP LIMA (620 Portugalsko), Rita DELGADO (620 Portugalsko) a Petr HERMANN (203 Česká republika, domácí)

Vydání

Wroclaw, Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015), od s. 118-119, 2 s. 2015

Nakladatel

University of Wroclaw

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Kód RIV

RIV/00216224:14310/15:00081670

Organizační jednotka

Přírodovědecká fakulta

ISSN

Klíčová slova anglicky

Copper(II) ion; macrocyclic ligands

Štítky

AKR

Změněno: 28. 4. 2016 15:53, Ing. Andrea Mikešková

Anotace

V originále

Tetraaza-macrocyclic ligands based on cyclen skeleton are well known for their great ability to bind copper(II) ion leading to formation of metal complexes of high thermodynamic stability and kinetic inertness which are required for their in vivo applications and in medicine. Some complexes of copper radioisotopes are utilized in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h). In addition, the sodium and potassium ions play an important role in biology, e.g. concentration gradient of sodium/potassium ions is important in living organism for many cell functions, and their presence in the solution can affect the kinetic inertness of copper(II) complexes. In this work, the acid-assisted dissociation kinetics of Cu(II) complexes with DOTP-like ligands (e.g. H6do3p, H6do3p1ol, H8dotp) was studied by means of molecular absorption spectroscopy in presence of Li+, Na+ and K+ salts employed as supporting electrolyte. It was found out that these ions significantly influence the rate of dissociation of copper(II) complex in K+ < Na+ < Li+ order and the parameters of chemical model describing this reaction correlate with their ionic size. This effect was not observed for analogous H4dota ligand. This phenomenon is important for interpretation of reaction mechanism of copper(II) complex dissociation and it can be explained by formation of weak complexes between the phosphonate group and the alkali metal ions, analogously as described for lanthanide(III) complexes of DOTP.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GA13-08336S, projekt VaV

Název: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Investor: Grantová agentura ČR, Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně

Citovat

MICHALICOVÁ, Romana, Přemysl LUBAL, Luis MP LIMA, Rita DELGADO a Petr HERMANN. Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands. In Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015). Wroclaw: University of Wroclaw, 2015, s. 118-119. ISSN 2239-2459.

@inproceedings{1340841,
   author = {Michalicová, Romana and Lubal, Přemysl and Lima, Luis MP and Delgado, Rita and Hermann, Petr},
   address = {Wroclaw},
   booktitle = {Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015)},
   keywords = {Copper(II) ion; macrocyclic ligands},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Wroclaw},
   pages = {118-119},
   publisher = {University of Wroclaw},
   title = {Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands},
   year = {2015}
}

TY  - JOUR
ID  - 1340841
AU  - Michalicová, Romana - Lubal, Přemysl - Lima, Luis MP - Delgado, Rita - Hermann, Petr
PY  - 2015
TI  - Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands
PB  - University of Wroclaw
CY  - Wroclaw
KW  - Copper(II) ion
KW  - macrocyclic ligands
N2  - Tetraaza-macrocyclic ligands based on cyclen skeleton are well known for their great ability to bind copper(II) ion leading to formation of metal complexes of high thermodynamic stability and kinetic inertness which are required for their in vivo applications and in medicine. Some complexes of copper radioisotopes are utilized in diagnosis (positron emission tomography - PET, 64Cu with half-life 12.8 h) or in radio-immunotherapy (67Cu with half-life 62 h). In addition, the sodium and potassium ions play an important role in biology, e.g. concentration gradient of sodium/potassium ions is important in living organism for many cell functions, and their presence in the solution can affect the kinetic inertness of copper(II) complexes. In this work, the acid-assisted dissociation kinetics of Cu(II) complexes with DOTP-like ligands (e.g. H6do3p, H6do3p1ol, H8dotp) was studied by means of molecular absorption spectroscopy in presence of Li+, Na+ and K+ salts employed as supporting electrolyte. It was found out that these ions significantly influence the rate of dissociation of copper(II) complex in K+ < Na+ < Li+ order and the parameters of chemical model describing this reaction correlate with their ionic size. This effect was not observed for analogous H4dota ligand. This phenomenon is important for interpretation of reaction mechanism of copper(II) complex dissociation and it can be explained by formation of weak complexes between the phosphonate group and the alkali metal ions, analogously as described for lanthanide(III) complexes of DOTP.
ER  -

MICHALICOVÁ, Romana, Přemysl LUBAL, Luis MP LIMA, Rita DELGADO a Petr HERMANN. Effect of alkali metal ions on dissociation kinetics of Cu(II) complexes of DOTP-like macrocyclic ligands. In \textit{Acta of the International Symposia on Metal Complexes – ISMEC Acta vol. 5 (2015)}. Wroclaw: University of Wroclaw, 2015, s.~118-119. ISSN~2239-2459.

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