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@inproceedings{1340854,
author = {Bartošková, Marie and Vaněk, Jakub and Bím, Daniel and Lubal, Přemysl and Hodačová, Jana},
address = {Wroclaw},
booktitle = {Acta of the International Symposia on Metal Complexes – ISMEC Acta Vol.5 (2015)},
keywords = {coper(II) ion; bis(macrocyclic) ligand},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Wroclaw},
pages = {70-71},
publisher = {University of Wroclaw},
title = {Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity},
year = {2015}
}
TY - JOUR
ID - 1340854
AU - Bartošková, Marie - Vaněk, Jakub - Bím, Daniel - Lubal, Přemysl - Hodačová, Jana
PY - 2015
TI - Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity
PB - University of Wroclaw
CY - Wroclaw
KW - coper(II) ion
KW - bis(macrocyclic) ligand
N2 - Polyaza-macrocyclic ligands are recently utilized to bind some radioisotopes for application in medicinal chemistry (60–64,67Cu, 66–68Ga, 86,90Y, 111In) [1,2] and the formed metal complexes of high thermodynamic stability and kinetic inertness are required for their use in vivo for medical purposes. Several copper(II) and zinc(II) complexes of bis-polyaza-macrocyclic ligands catalyse some chemical reactions and therefore they can be used as model systems mimicking enzymes activity. In this work, the protonation constants of novel macrocyclic ligands as well as stability constants of their copper(II) and zinc(II) complexes were determined by glass-electrode potentiometry and molecular absorption spectroscopy. The formation of the copper(II) complexes of both ligands is accelerated with increased pH. The dissociation of both copper(II) complexes does not differ within experimental error indicating no cooperative effect for binucleating ligand. However, both complexes demonstrate significant catalytic activity in hydrolysis of model phosphodiester compounds.
ER -
BARTOŠKOVÁ, Marie, Jakub VANĚK, Daniel BÍM, Přemysl LUBAL and Jana HODAČOVÁ. Thermodynamic and Kinetic Study of Mono- and Bis-triazamacrocyclic Ligands and their Transition Metal Complexes Mimicking Hydrolytic Enzyme Activity. In \textit{Acta of the International Symposia on Metal Complexes – ISMEC Acta Vol.5 (2015)}. Wroclaw: University of Wroclaw, 2015, p.~70-71. ISSN~2239-2459.
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