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@article{1343118, author = {Kovaľová, Ivana and Vlčková, Eva and Bednařík, Josef}, article_location = {Hoboken}, article_number = {3}, doi = {http://dx.doi.org/10.1002/brb3.444}, keywords = {cervical spondylotic myelopathy; epidermal nerve fibers; neuropathic pain; peripheral neuropathy; skin biopsy}, language = {eng}, issn = {2162-3279}, journal = {Brain and Behavior}, title = {Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet}, volume = {6}, year = {2016} }
TY - JOUR ID - 1343118 AU - Kovaľová, Ivana - Vlčková, Eva - Bednařík, Josef PY - 2016 TI - Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet JF - Brain and Behavior VL - 6 IS - 3 SP - 1-5 EP - 1-5 PB - John Wiley and Sons Inc. SN - 21623279 KW - cervical spondylotic myelopathy KW - epidermal nerve fibers KW - neuropathic pain KW - peripheral neuropathy KW - skin biopsy N2 - Purpose: Intraepidermal nerve fiber density (IENFD) is useful in the evaluation of small-fiber neuropathy (SFN). Recent guidelines recommend extending the spectrum of controls for IENFD assessment by evaluation of patients whose clinical picture mimics that of SFN. The aim of this study was to broaden the spectrum of IENFD controls by the assessment of patients with cervical spondylotic myelopathy (CSM) and painful feet. Methods: Evaluation of IENFD from skin biopsy samples and quantitative sensory testing (QST) were performed in a cohort of 14 CSM patients (eight men, median age: 58; range: 46–63 years), with painful feet, exhibiting no clinical or electrophysiological signs of largefiber polyneuropathy, and no risk factors for peripheral neuropathies. Results: Quantitative sensory testing abnormalities were found in all but two of the CSM patients (86%), while the IENFD values were within reference range. The mean IENFD value (6.87 2.78 fibers/mm) did not differ from that of an ageand sex-matched cohort of healthy volunteers (7.97 2.21 fibers/mm, P > 0.05). Conclusions: The study confirmed normal skin biopsy findings in patients with CSM as one of the clinical conditions mimicking SFN and provided further support for the use of IENFD assessment in case of suspicion of SFN. ER -
KOVAĽOVÁ, Ivana, Eva VLČKOVÁ a Josef BEDNAŘÍK. Broadening the spectrum of controls for skin biopsy in painful neuropathies: spondylotic cervical myelopathy patients with painful feet. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2016, roč.~6, č.~3, s.~1-5. ISSN~2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.444.
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