Dysfunctional protection against advanced glycation due to
thiamine metabolism abnormalities in gestational diabetes

J 2016

Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes

BARTÁKOVÁ, Vendula, Anna PLESKAČOVÁ, Katarína KURICOVÁ, Lukáš PÁCAL, Veronika DVOŘÁKOVÁ et. al.

Základní údaje

Originální název

Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes

Autoři

BARTÁKOVÁ, Vendula (203 Česká republika, garant, domácí), Anna PLESKAČOVÁ (203 Česká republika, domácí), Katarína KURICOVÁ (703 Slovensko, domácí), Lukáš PÁCAL (203 Česká republika, domácí), Veronika DVOŘÁKOVÁ (203 Česká republika, domácí), Jana BĚLOBRÁDKOVÁ (203 Česká republika), Marie TOMANDLOVÁ (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí) a Kateřina KAŇKOVÁ (203 Česká republika, domácí)

Vydání

Glycoconjugate Journal, Dordrecht, Springer, 2016, 0282-0080

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Impakt faktor

Impact factor: 2.186

Kód RIV

RIV/00216224:14110/16:00088860

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s10719-016-9688-9

UT WoS

000381157600011

Klíčová slova česky

tiamin, gestační diabetes, těhotenství, pokročilé produkty glykace

Klíčová slova anglicky

thiamine; gestational diabetes mellitus; pregnancy; advanced glycation end porducts

Štítky

EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 12. 2019 11:32, Mgr. Marie Šípková, DiS.

Anotace

V originále

While the pathogenic role of dicarbonyl stress and accelerated formation of advanced glycation end products (AGEs) to glucose intolerance and to the development of diabetic complications is well established, little is known about these processes in gestational diabetes mellitus (GDM), a condition pathogenically quite similar to type 2 diabetes. The aims of the present study were (i) to determine plasma thiamine and erythrocyte thiamine diphosphate (TDP) and transketolase (TKT) activity in pregnant women with and without GDM, (ii) to assess relationships between thiamine metabolism parameters and selected clinical, biochemical and anthropometric characteristics and, finally, (iii) to analyse relationship between variability in the genes involved in the regulation of transmembrane thiamine transport (i.e. SLC19A2 and SLC19A3) and relevant parameters of thiamine metabolism. We found significantly lower plasma BMI adjusted thiamine in women with GDM (P = 0.002, Mann-Whitney) while levels of erythrocyte TDP (an active TKT cofactor) in mid-trimester were significantly higher in GDM compared to controls (P = 0.04, Mann-Whitney). However, mid-gestational TKT activity - reflecting pentose phosphate pathway activity - did not differ between the two groups (P > 0.05, Mann-Whitney). Furthermore, we ascertained significant associations of postpartum TKT activity with SNPs SLC19A2 rs6656822 and SLC19A3 rs7567984 (P = 0.03 and P = 0.007, resp., Kruskal-Wallis). Our findings of increased thiamine delivery to the cells without concomitant increase of TKT activity in women with GDM therefore indicate possible pathogenic role of thiamine mishandling in GDM. Further studies are needed to determine its contribution to maternal and/or neonatal morbidity.

Návaznosti

NT13198, projekt VaV

Název: Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací

Investor: Ministerstvo zdravotnictví ČR, Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací

Citovat

BARTÁKOVÁ, Vendula, Anna PLESKAČOVÁ, Katarína KURICOVÁ, Lukáš PÁCAL, Veronika DVOŘÁKOVÁ, Jana BĚLOBRÁDKOVÁ, Marie TOMANDLOVÁ, Josef TOMANDL a Kateřina KAŇKOVÁ. Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes. Glycoconjugate Journal. Dordrecht: Springer, 2016, roč. 33, č. 4, s. 591-598. ISSN 0282-0080. Dostupné z: https://dx.doi.org/10.1007/s10719-016-9688-9.

@article{1347537,
   author = {Bartáková, Vendula and Pleskačová, Anna and Kuricová, Katarína and Pácal, Lukáš and Dvořáková, Veronika and Bělobrádková, Jana and Tomandlová, Marie and Tomandl, Josef and Kaňková, Kateřina},
   article_location = {Dordrecht},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s10719-016-9688-9},
   keywords = {thiamine; gestational diabetes mellitus; pregnancy; advanced glycation end porducts},
   language = {eng},
   issn = {0282-0080},
   journal = {Glycoconjugate Journal},
   title = {Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes},
   url = {http://link.springer.com/article/10.1007/s10719-016-9688-9},
   volume = {33},
   year = {2016}
}

TY  - JOUR
ID  - 1347537
AU  - Bartáková, Vendula - Pleskačová, Anna - Kuricová, Katarína - Pácal, Lukáš - Dvořáková, Veronika - Bělobrádková, Jana - Tomandlová, Marie - Tomandl, Josef - Kaňková, Kateřina
PY  - 2016
TI  - Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes
JF  - Glycoconjugate Journal
VL  - 33
IS  - 4
SP  - 591-598
EP  - 591-598
PB  - Springer
SN  - 02820080
KW  - thiamine
KW  - gestational diabetes mellitus
KW  - pregnancy
KW  - advanced glycation end porducts
UR  - http://link.springer.com/article/10.1007/s10719-016-9688-9
L2  - http://link.springer.com/article/10.1007/s10719-016-9688-9
N2  - While the pathogenic role of dicarbonyl stress and accelerated formation of advanced glycation end products (AGEs) to glucose intolerance and to the development of diabetic complications is well established, little is known about these processes in gestational diabetes mellitus (GDM), a condition pathogenically quite similar to type 2 diabetes. The aims of the present study were (i) to determine plasma thiamine and erythrocyte thiamine diphosphate (TDP) and transketolase (TKT) activity in pregnant women with and without GDM, (ii) to assess relationships between thiamine metabolism parameters and selected clinical, biochemical and anthropometric characteristics and, finally, (iii) to analyse relationship between variability in the genes involved in the regulation of transmembrane thiamine transport (i.e. SLC19A2 and SLC19A3) and relevant parameters of thiamine metabolism. We found significantly lower plasma BMI adjusted thiamine in women with GDM (P = 0.002, Mann-Whitney) while levels of erythrocyte TDP (an active TKT cofactor) in mid-trimester were significantly higher in GDM compared to controls (P = 0.04, Mann-Whitney). However, mid-gestational TKT activity - reflecting pentose phosphate pathway activity - did not differ between the two groups (P > 0.05, Mann-Whitney). Furthermore, we ascertained significant associations of postpartum TKT activity with SNPs SLC19A2 rs6656822 and SLC19A3 rs7567984 (P = 0.03 and P = 0.007, resp., Kruskal-Wallis). Our findings of increased thiamine delivery to the cells without concomitant increase of TKT activity in women with GDM therefore indicate possible pathogenic role of thiamine mishandling in GDM. Further studies are needed to determine its contribution to maternal and/or neonatal morbidity.
ER  -

BARTÁKOVÁ, Vendula, Anna PLESKAČOVÁ, Katarína KURICOVÁ, Lukáš PÁCAL, Veronika DVOŘÁKOVÁ, Jana BĚLOBRÁDKOVÁ, Marie TOMANDLOVÁ, Josef TOMANDL a Kateřina KAŇKOVÁ. Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes. \textit{Glycoconjugate Journal}. Dordrecht: Springer, 2016, roč.~33, č.~4, s.~591-598. ISSN~0282-0080. Dostupné z: https://dx.doi.org/10.1007/s10719-016-9688-9.

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