Cellular reactions of the choroid plexus induced by peripheral
nerve injury

J 2016

Cellular reactions of the choroid plexus induced by peripheral nerve injury

JOUKAL, Marek, Ilona KLUSÁKOVÁ, Peter SOLÁR, Adéla KUKLOVÁ, Petr DUBOVÝ et. al.

Základní údaje

Originální název

Cellular reactions of the choroid plexus induced by peripheral nerve injury

Autoři

JOUKAL, Marek (203 Česká republika, garant, domácí), Ilona KLUSÁKOVÁ (203 Česká republika, domácí), Peter SOLÁR (703 Slovensko, domácí), Adéla KUKLOVÁ (203 Česká republika, domácí) a Petr DUBOVÝ (203 Česká republika, domácí)

Vydání

Neuroscience Letters, Clare, Elsevier Ireland Ltd. 2016, 0304-3940

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.180

Kód RIV

RIV/00216224:14110/16:00090251

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.neulet.2016.06.019

UT WoS

000381590800012

Klíčová slova anglicky

Blood-cerebrospinal fluid barrier; Kolmer cells; Macrophages; Chronic constriction injury

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 10. 2016 12:15, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

The choroid plexus (CP) of brain ventricles forms the blood-cerebrospinal fluid (blood-CSF) barrier that is involved in many diseases affecting the central nervous system (CNS). We used ED1 and ED2 immunostaining to investigate epiplexus cell changes in rat CP after chronic constriction injury (CCI). In contrast to naive CP, the CP of sham-operated rats showed an increase in the number of ED1+ cells of a similar magnitude during all periods of survival up to 3 weeks, while the number of ED2+ increased only at 3 days from operation. In comparison to naive and sham-operated animals, the number of ED1+ and ED2+ cells in the epiplexus position increased with the duration of nerve compression. We detected no or negligible cell proliferation in the CP after sham- or CCI-operation. This suggests that increased number of ED1+ and ED2+ cells in the epiplexus position of the CP is derived from peripheral monocytes passing through altered blood-CSF barrier. The changes in epiplexus cells indicate that the CP reacts to tissue injury after the surgical approach itself and that the response to peripheral nerve lesion is greater. This suggests a role for an altered blood-CSF barrier allowing for propagation of signal molecules from damaged tissue and nerve to the CNS.

Návaznosti

MUNI/A/1268/2015, interní kód MU

Název: Studium vlivu paclitaxelu na hemato-likvorovou bariéru

Investor: Masarykova univerzita, Studium vlivu paclitaxelu na hemato-likvorovou bariéru, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

JOUKAL, Marek, Ilona KLUSÁKOVÁ, Peter SOLÁR, Adéla KUKLOVÁ a Petr DUBOVÝ. Cellular reactions of the choroid plexus induced by peripheral nerve injury. Neuroscience Letters. Clare: Elsevier Ireland Ltd., 2016, roč. 628, "neuvedeno", s. 73-77. ISSN 0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2016.06.019.

@article{1348293,
   author = {Joukal, Marek and Klusáková, Ilona and Solár, Peter and Kuklová, Adéla and Dubový, Petr},
   article_location = {Clare},
   article_number = {"neuvedeno"},
   doi = {http://dx.doi.org/10.1016/j.neulet.2016.06.019},
   keywords = {Blood-cerebrospinal fluid barrier; Kolmer cells; Macrophages; Chronic constriction injury},
   language = {eng},
   issn = {0304-3940},
   journal = {Neuroscience Letters},
   title = {Cellular reactions of the choroid plexus induced by peripheral nerve injury},
   volume = {628},
   year = {2016}
}

TY  - JOUR
ID  - 1348293
AU  - Joukal, Marek - Klusáková, Ilona - Solár, Peter - Kuklová, Adéla - Dubový, Petr
PY  - 2016
TI  - Cellular reactions of the choroid plexus induced by peripheral nerve injury
JF  - Neuroscience Letters
VL  - 628
IS  - "neuvedeno"
SP  - 73-77
EP  - 73-77
PB  - Elsevier Ireland Ltd.
SN  - 03043940
KW  - Blood-cerebrospinal fluid barrier
KW  - Kolmer cells
KW  - Macrophages
KW  - Chronic constriction injury
N2  - The choroid plexus (CP) of brain ventricles forms the blood-cerebrospinal fluid (blood-CSF) barrier that is involved in many diseases affecting the central nervous system (CNS). We used ED1 and ED2 immunostaining to investigate epiplexus cell changes in rat CP after chronic constriction injury (CCI). In contrast to naive CP, the CP of sham-operated rats showed an increase in the number of ED1+ cells of a similar magnitude during all periods of survival up to 3 weeks, while the number of ED2+ increased only at 3 days from operation. In comparison to naive and sham-operated animals, the number of ED1+ and ED2+ cells in the epiplexus position increased with the duration of nerve compression. We detected no or negligible cell proliferation in the CP after sham- or CCI-operation. This suggests that increased number of ED1+ and ED2+ cells in the epiplexus position of the CP is derived from peripheral monocytes passing through altered blood-CSF barrier. The changes in epiplexus cells indicate that the CP reacts to tissue injury after the surgical approach itself and that the response to peripheral nerve lesion is greater. This suggests a role for an altered blood-CSF barrier allowing for propagation of signal molecules from damaged tissue and nerve to the CNS.
ER  -

JOUKAL, Marek, Ilona KLUSÁKOVÁ, Peter SOLÁR, Adéla KUKLOVÁ a Petr DUBOVÝ. Cellular reactions of the choroid plexus induced by peripheral nerve injury. \textit{Neuroscience Letters}. Clare: Elsevier Ireland Ltd., 2016, roč.~628, ''neuvedeno'', s.~73-77. ISSN~0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2016.06.019.

Podrobný výpis o publikaci