Late-stage annulative convergency in natural product synthesis

J 2016

Late-stage annulative convergency in natural product synthesis

HILL, N., Kamil PARUCH a Jakub ŠVENDA

Základní údaje

Originální název

Late-stage annulative convergency in natural product synthesis

Autoři

HILL, N. (840 Spojené státy), Kamil PARUCH (203 Česká republika, domácí) a Jakub ŠVENDA (203 Česká republika, domácí)

Vydání

Tetrahedron, OXFORD, Pergamon Press, 2016, 0040-4020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.651

Kód RIV

RIV/00216224:14310/16:00090349

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.tet.2016.04.004

UT WoS

000377324600001

Klíčová slova anglicky

Convergent synthesis; Annulation; Convergency; Natural products; Organic synthesis

Štítky

AKR, rivok

Změněno: 20. 3. 2017 09:42, Mgr. Jakub Švenda, PhD.

Anotace

V originále

In this Review, we present illustrative examples of recent synthesesof complex natural products completed through the latestage convergent coupling of fragments of similar size in either i) an annulation reaction or ii) a short, small ring-forming reaction sequence. The term we use to describe these criteria is late-stage annulative convergency. We focus on such bond-pair retrosynthetic disconnections because they can be more challenging to recognize and often result in a greater degree of structural simplification. While not covered here, the general benefits of a convergent strategy apply equally to single-bond couplings or larger ring constructions (e.g., linear and macrocyclic molecules). The Review covers the literature from 2000 through the end of 2015 and is intended to present highlights of late-stage annulative convergency rather than an exhaustive coverage of total syntheses with convergent features.

Citovat

HILL, N., Kamil PARUCH a Jakub ŠVENDA. Late-stage annulative convergency in natural product synthesis. Tetrahedron. OXFORD: Pergamon Press, 2016, roč. 72, č. 24, s. 3345-3368. ISSN 0040-4020. Dostupné z: https://dx.doi.org/10.1016/j.tet.2016.04.004.

@article{1349540,
   author = {Hill, N. and Paruch, Kamil and Švenda, Jakub},
   article_location = {OXFORD},
   article_number = {24},
   doi = {http://dx.doi.org/10.1016/j.tet.2016.04.004},
   keywords = {Convergent synthesis; Annulation; Convergency; Natural products; Organic synthesis},
   language = {eng},
   issn = {0040-4020},
   journal = {Tetrahedron},
   title = {Late-stage annulative convergency in natural product synthesis},
   url = {http://www.sciencedirect.com/science/article/pii/S0040402016302575},
   volume = {72},
   year = {2016}
}

TY  - JOUR
ID  - 1349540
AU  - Hill, N. - Paruch, Kamil - Švenda, Jakub
PY  - 2016
TI  - Late-stage annulative convergency in natural product synthesis
JF  - Tetrahedron
VL  - 72
IS  - 24
SP  - 3345-3368
EP  - 3345-3368
PB  - Pergamon Press
SN  - 00404020
KW  - Convergent synthesis
KW  - Annulation
KW  - Convergency
KW  - Natural products
KW  - Organic synthesis
UR  - http://www.sciencedirect.com/science/article/pii/S0040402016302575
L2  - http://www.sciencedirect.com/science/article/pii/S0040402016302575
N2  - In this Review, we present illustrative examples of recent synthesesof complex natural products completed through the latestage convergent coupling of fragments of similar size in either i) an annulation reaction or ii) a short, small ring-forming reaction sequence. The term we use to describe these criteria is late-stage annulative convergency. We focus on such bond-pair retrosynthetic disconnections because they can be more challenging to recognize and often result in a greater degree of structural simplification. While not covered here, the general benefits of a convergent strategy apply equally to single-bond couplings or larger ring constructions (e.g., linear and macrocyclic molecules). The Review covers the literature from 2000 through the end of 2015 and is intended to present highlights of late-stage annulative convergency rather than an exhaustive coverage of total syntheses with convergent features.
ER  -

HILL, N., Kamil PARUCH a Jakub ŠVENDA. Late-stage annulative convergency in natural product synthesis. \textit{Tetrahedron}. OXFORD: Pergamon Press, 2016, roč.~72, č.~24, s.~3345-3368. ISSN~0040-4020. Dostupné z: https://dx.doi.org/10.1016/j.tet.2016.04.004.

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