| GASPAR, Ludovit, Andrea KOMORNIKOVA, Peter KRUZLIAK, Luis RODRIGO, Zufar GABBASOV, Robert STAFFA, Alexander BEREZIN, Peter GAVORNIK, Andrej DUKAT, Ewald AMBROZY, Matej BENDZALA a Peter SABAKA. Contribution of prostaglandin E1 treatment in patients with critical limb ischemia. International Journal of Clinical and Experimental Medicine. Madison: e-Century Publishing Corporation, 2016, roč. 9, č. 2, s. 3227-3231. ISSN 1940-5901. |
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@article{1349547,
author = {Gaspar, Ludovit and Komornikova, Andrea and Kruzliak, Peter and Rodrigo, Luis and Gabbasov, Zufar and Staffa, Robert and Berezin, Alexander and Gavornik, Peter and Dukat, Andrej and Ambrozy, Ewald and Bendzala, Matej and Sabaka, Peter},
article_location = {Madison},
article_number = {2},
keywords = {Peripheral arterial disease; critical limb ischemia; prostaglandin treatment; major amputations; prognosis},
language = {eng},
issn = {1940-5901},
journal = {International Journal of Clinical and Experimental Medicine},
title = {Contribution of prostaglandin E1 treatment in patients with critical limb ischemia},
volume = {9},
year = {2016}
}
TY - JOUR
ID - 1349547
AU - Gaspar, Ludovit - Komornikova, Andrea - Kruzliak, Peter - Rodrigo, Luis - Gabbasov, Zufar - Staffa, Robert - Berezin, Alexander - Gavornik, Peter - Dukat, Andrej - Ambrozy, Ewald - Bendzala, Matej - Sabaka, Peter
PY - 2016
TI - Contribution of prostaglandin E1 treatment in patients with critical limb ischemia
JF - International Journal of Clinical and Experimental Medicine
VL - 9
IS - 2
SP - 3227-3231
EP - 3227-3231
PB - e-Century Publishing Corporation
SN - 19405901
KW - Peripheral arterial disease
KW - critical limb ischemia
KW - prostaglandin treatment
KW - major amputations
KW - prognosis
N2 - Background and aims: Peripheral arterial disease (PAD) in advanced stages has severe disabling complications. Major amputations (MA) and high mortality rates are common in patients with critical limb ischemia (CLI). Revascularization (interventional angioplasty or vascular surgery) appears to be possible in the large majority of cases if these patients are referred to a specialist earlier. Patients with CLI and lacking options for revascularization have worse prognosis. The purpose of this retrospective study was to investigate the impact of including prostaglandins in the treatment of patients with CLI lacking the possibility of revascularization. Method: This retrospective study cohort includes 67 patients (34 male and 33 female), mean age 71 +/- 10.7 years treated for CLI not suitable for revascularization. Prostaglandin E1 (alprostadil) was applied by intravenous perfusion with doses of 40 mu g twice a day for 2 weeks. Results: 23 patients (34.3%) underwent amputation and 17 patients (40.3%) died during the total follow-up period (01/2009-07/2014). Mortality rate was higher in patients who have undergone an amputation, in diabetics and in patients without statin medication. Conclusion: Patients with CLI lacking options for revascularization have despite treatment with prostanoids (alprostadil) a poor prognosis, with high amputation rate and increased mortality. Statin medication was a protective factor for survival.
ER -
GASPAR, Ludovit, Andrea KOMORNIKOVA, Peter KRUZLIAK, Luis RODRIGO, Zufar GABBASOV, Robert STAFFA, Alexander BEREZIN, Peter GAVORNIK, Andrej DUKAT, Ewald AMBROZY, Matej BENDZALA a Peter SABAKA. Contribution of prostaglandin E1 treatment in patients with critical limb ischemia. \textit{International Journal of Clinical and Experimental Medicine}. Madison: e-Century Publishing Corporation, 2016, roč.~9, č.~2, s.~3227-3231. ISSN~1940-5901.
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