Altered Neural Correlate of the Self-Agency Experience in
First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

J 2016

Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

SPANIEL, Filip, Jaroslav TINTERA, Jan RYDLO, Ibrahim IBRAHIM, Tomáš KAŠPÁREK et. al.

Basic information

Original name

Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study

Authors

SPANIEL, Filip (203 Czech Republic), Jaroslav TINTERA (203 Czech Republic), Jan RYDLO (203 Czech Republic), Ibrahim IBRAHIM (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic, guarantor, belonging to the institution), Jiri HORACEK (203 Czech Republic), Natalie ZAYTSEVA (203 Czech Republic), Martin MATEJKA (203 Czech Republic), Marketa FIALOVA (203 Czech Republic), Andrea SLOVAKOVA (203 Czech Republic), Pavol MIKOLAS (203 Czech Republic), Tomas MELICHER (203 Czech Republic), Natalie GÖRNEROVA (203 Czech Republic), Cyril HÖSCHL (203 Czech Republic) and Tomas HAJEK (203 Czech Republic)

Edition

Schizophrenia Bulletin, Oxford, Oxford University Press, 2016, 0586-7614

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 7.575

RIV identification code

RIV/00216224:14110/16:00090378

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/schbul/sbv188

UT WoS

000385280800013

Keywords in English

first-episode schizophrenia; neuroimaging; fMRI; self-agency; independent component analysis

Abstract

V originále

Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Citovat

SPANIEL, Filip, Jaroslav TINTERA, Jan RYDLO, Ibrahim IBRAHIM, Tomáš KAŠPÁREK, Jiri HORACEK, Natalie ZAYTSEVA, Martin MATEJKA, Marketa FIALOVA, Andrea SLOVAKOVA, Pavol MIKOLAS, Tomas MELICHER, Natalie GÖRNEROVA, Cyril HÖSCHL and Tomas HAJEK. Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study. Schizophrenia Bulletin. Oxford: Oxford University Press, 2016, vol. 42, No 4, p. 916-925. ISSN 0586-7614. Available from: https://dx.doi.org/10.1093/schbul/sbv188.

@article{1349625,
   author = {Spaniel, Filip and Tintera, Jaroslav and Rydlo, Jan and Ibrahim, Ibrahim and Kašpárek, Tomáš and Horacek, Jiri and Zaytseva, Natalie and Matejka, Martin and Fialova, Marketa and Slovakova, Andrea and Mikolas, Pavol and Melicher, Tomas and Görnerova, Natalie and Höschl, Cyril and Hajek, Tomas},
   article_location = {Oxford},
   article_number = {4},
   doi = {http://dx.doi.org/10.1093/schbul/sbv188},
   keywords = {first-episode schizophrenia; neuroimaging; fMRI; self-agency; independent component analysis},
   language = {eng},
   issn = {0586-7614},
   journal = {Schizophrenia Bulletin},
   title = {Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study},
   volume = {42},
   year = {2016}
}

TY  - JOUR
ID  - 1349625
AU  - Spaniel, Filip - Tintera, Jaroslav - Rydlo, Jan - Ibrahim, Ibrahim - Kašpárek, Tomáš - Horacek, Jiri - Zaytseva, Natalie - Matejka, Martin - Fialova, Marketa - Slovakova, Andrea - Mikolas, Pavol - Melicher, Tomas - Görnerova, Natalie - Höschl, Cyril - Hajek, Tomas
PY  - 2016
TI  - Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study
JF  - Schizophrenia Bulletin
VL  - 42
IS  - 4
SP  - 916-925
EP  - 916-925
PB  - Oxford University Press
SN  - 05867614
KW  - first-episode schizophrenia
KW  - neuroimaging
KW  - fMRI
KW  - self-agency
KW  - independent component analysis
N2  - Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P < .05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.
ER  -

SPANIEL, Filip, Jaroslav TINTERA, Jan RYDLO, Ibrahim IBRAHIM, Tomáš KAŠPÁREK, Jiri HORACEK, Natalie ZAYTSEVA, Martin MATEJKA, Marketa FIALOVA, Andrea SLOVAKOVA, Pavol MIKOLAS, Tomas MELICHER, Natalie GÖRNEROVA, Cyril HÖSCHL and Tomas HAJEK. Altered Neural Correlate of the Self-Agency Experience in First-Episode Schizophrenia-Spectrum Patients: An fMRI Study. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2016, vol.~42, No~4, p.~916-925. ISSN~0586-7614. Available from: https://dx.doi.org/10.1093/schbul/sbv188.

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