Neuronal substrate and effective connectivity of abnormal
movement sequencing in schizophrenia

J 2016

Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia

ZEMÁNKOVÁ, Petra, Ovidiu LUNGU, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ, Jozef ŽÚBOR et. al.

Základní údaje

Originální název

Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia

Autoři

ZEMÁNKOVÁ, Petra (203 Česká republika, garant, domácí), Ovidiu LUNGU (124 Kanada), Jitka HÜTTLOVÁ (203 Česká republika, domácí), Miloš KEŘKOVSKÝ (203 Česká republika, domácí), Jozef ŽÚBOR (703 Slovensko, domácí), Petra LIPOVÁ (203 Česká republika), Martin BAREŠ (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, domácí)

Vydání

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2016, 0278-5846

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.187

Kód RIV

RIV/00216224:14740/16:00088867

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.pnpbp.2016.01.003

UT WoS

000371795200001

Klíčová slova anglicky

Schizophrenia; Movement sequencing; Neurological soft signs; fMRI; Effective connectivity

Štítky

EL OK, podil, rivok

Změněno: 5. 8. 2016 11:05, Mgr. Eva Špillingová

Anotace

V originále

Movement sequencing difficulties are part of the neurological soft signs (NSS), they have high clinical value because they are not always present in schizophrenia. We investigated the neuronal correlates of movement sequencing in 24 healthy controls and 24 schizophrenia patients, with (SZP SQ+) or without (SZP SQ-) sequencing difficulties. We characterized simultaneous and lagged functional connectivity between brain regions involved in movement sequencing using psychophysiological interaction (PPI) and the Granger causality modeling (GCM), respectively. Left premotor cortex (PMC) and superior parietal lobule (SPL) were specifically activated during sequential movements in all participants. Right PMC and precuneus, ipsilateral to the hand executing the task, activated during sequential movements only in healthy controls and SZP SQ-. SZP SQ+ showed hyper-activation in contralateral PMC, as compared to the other groups. PPI analysis revealed a deficit in inhibitory connections within this fronto-parietal network in SZP SQ+ during sequential task. GCM showed a significant lagged effective connectivity from right PMC to left SPL during task and rest periods in all groups and from right PMC to right precuneus in SZP SQ+ group only. Both SZP groups had a significant lagged connectivity from right to left PMC, during sequential task. Our results indicate that aberrant fronto-parietal network connectivity with cortical inhibition deficit and abnormal reliance on previous network activity are related to movement sequencing in SZP. The overactivation of motor cortex seems to be a good compensating strategy, the hyperactivation of parietal cortex is linked to motor deficit symptoms. (C) 2016 Elsevier Inc. All rights reserved.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13437, projekt VaV

Název: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Přiložené soubory

EL_1349638.pdf

Požádat o autorskou verzi souboru

Citovat

ZEMÁNKOVÁ, Petra, Ovidiu LUNGU, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ, Jozef ŽÚBOR, Petra LIPOVÁ, Martin BAREŠ a Tomáš KAŠPÁREK. Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2016, roč. 67, June, s. 1-9. ISSN 0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2016.01.003.

@article{1349638,
   author = {Zemánková, Petra and Lungu, Ovidiu and Hüttlová, Jitka and Keřkovský, Miloš and Žúbor, Jozef and Lipová, Petra and Bareš, Martin and Kašpárek, Tomáš},
   article_location = {OXFORD},
   article_number = {June},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2016.01.003},
   keywords = {Schizophrenia; Movement sequencing; Neurological soft signs; fMRI; Effective connectivity},
   language = {eng},
   issn = {0278-5846},
   journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY},
   title = {Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia},
   url = {http://www.sciencedirect.com/science/article/pii/S0278584616300033},
   volume = {67},
   year = {2016}
}

TY  - JOUR
ID  - 1349638
AU  - Zemánková, Petra - Lungu, Ovidiu - Hüttlová, Jitka - Keřkovský, Miloš - Žúbor, Jozef - Lipová, Petra - Bareš, Martin - Kašpárek, Tomáš
PY  - 2016
TI  - Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia
JF  - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
VL  - 67
IS  - June
SP  - 1-9
EP  - 1-9
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - Schizophrenia
KW  - Movement sequencing
KW  - Neurological soft signs
KW  - fMRI
KW  - Effective connectivity
UR  - http://www.sciencedirect.com/science/article/pii/S0278584616300033
L2  - http://www.sciencedirect.com/science/article/pii/S0278584616300033
N2  - Movement sequencing difficulties are part of the neurological soft signs (NSS), they have high clinical value because they are not always present in schizophrenia. We investigated the neuronal correlates of movement sequencing in 24 healthy controls and 24 schizophrenia patients, with (SZP SQ+) or without (SZP SQ-) sequencing difficulties. We characterized simultaneous and lagged functional connectivity between brain regions involved in movement sequencing using psychophysiological interaction (PPI) and the Granger causality modeling (GCM), respectively. Left premotor cortex (PMC) and superior parietal lobule (SPL) were specifically activated during sequential movements in all participants. Right PMC and precuneus, ipsilateral to the hand executing the task, activated during sequential movements only in healthy controls and SZP SQ-. SZP SQ+ showed hyper-activation in contralateral PMC, as compared to the other groups. PPI analysis revealed a deficit in inhibitory connections within this fronto-parietal network in SZP SQ+ during sequential task. GCM showed a significant lagged effective connectivity from right PMC to left SPL during task and rest periods in all groups and from right PMC to right precuneus in SZP SQ+ group only. Both SZP groups had a significant lagged connectivity from right to left PMC, during sequential task. Our results indicate that aberrant fronto-parietal network connectivity with cortical inhibition deficit and abnormal reliance on previous network activity are related to movement sequencing in SZP. The overactivation of motor cortex seems to be a good compensating strategy, the hyperactivation of parietal cortex is linked to motor deficit symptoms. (C) 2016 Elsevier Inc. All rights reserved.
ER  -

ZEMÁNKOVÁ, Petra, Ovidiu LUNGU, Jitka HÜTTLOVÁ, Miloš KEŘKOVSKÝ, Jozef ŽÚBOR, Petra LIPOVÁ, Martin BAREŠ a Tomáš KAŠPÁREK. Neuronal substrate and effective connectivity of abnormal movement sequencing in schizophrenia. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{} BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2016, roč.~67, June, s.~1-9. ISSN~0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2016.01.003.

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