A Pooled Analysis of Reproductive Factors, Exogenous Hormone
Use, and Risk of Multiple Myeloma among Women in the
International Multiple Myeloma Consortium

J 2016

A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium

COSTAS, Laura; Brice H. LAMBERT; Brenda M. BIRMANN; Kirsten B. MOYSICH; Anneclaire J. De ROOS et. al.

Basic information

Original name

A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium

Authors

COSTAS, Laura (724 Spain); Brice H. LAMBERT (840 United States of America); Brenda M. BIRMANN (840 United States of America); Kirsten B. MOYSICH (840 United States of America); Anneclaire J. De ROOS (840 United States of America); Jonathan N. HOFMANN (840 United States of America); Dalsu BARIS (840 United States of America); Sophia S. WANG (840 United States of America); Nicola J. CAMP (840 United States of America); Guido TRICOT (840 United States of America); Djordje ATANACKOVIC (840 United States of America); Paul BRENNAN (250 France); Pierluigi COCCO (380 Italy); Alexandra NIETERS (276 Germany); Nikolaus BECKER (276 Germany); Marc MAYNADIÉ (250 France); Lenka FORETOVÁ (203 Czech Republic, guarantor, belonging to the institution); Paolo BOFFETTA (840 United States of America); Anthony STAINES (372 Ireland); Elisabeth E. BROWN (840 United States of America) and Silvia de SANJOSÉ (724 Spain)

Edition

Cancer Epidemiology Biomarkers & Prevention, Philadelphia, American Association for Cancer Research Inc. 2016, 1055-9965

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 4.142

RIV identification code

RIV/00216224:14110/16:00090429

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1158/1055-9965.EPI-15-0953

UT WoS

000372171400029

EID Scopus

2-s2.0-84955294772

Keywords in English

LYMPHOMAS; COHORT; HEALTH

Abstract

In the original language

Background: Female sex hormones are known to have immunomodulatory effects. Therefore, reproductive factors and exogenous hormone use could influence the risk of multiple myeloma in women. However, the role of hormonal factors in multiple myeloma etiology remains unclear because previous investigations were underpowered to detect modest associations. Methods: We conducted a pooled analysis of seven case-control studies included in the International Multiple Myeloma Consortium, with individual data on reproductive factors and exogenous hormone use from 1,072 female cases and 3,541 female controls. Study-specific odds ratios and corresponding 95% confidence intervals (CI) were estimated using logistic regression and pooled analyses were conducted using random effects meta-analyses. Results: Multiple myeloma was not associated with reproductive factors, including ever parous [OR = 0.92; 95% confidence interval (CI), 0.68-1.25], or with hormonal contraception use (OR = 1.04; 95% CI, 0.80-1.36). Postmenopausal hormone therapy users had nonsignificantly reduced risks of multiple myeloma compared with never users, but this association differed across centers (OR = 0.65; 95% CI, 0.37-1.15, I-2 = 76.0%, P-heterogeneity = 0.01). Conclusions: These data do not support a role for reproductive factors or exogenous hormones in myelomagenesis. Impact: Incidence rates of multiple myeloma are higher in men than in women, and sex hormones could influence this pattern. Associations with reproductive factors and exogenous hormone use were inconclusive despite our large sample size, suggesting that female sex hormones may not play a significant role in multiple myeloma etiology.

Cite

COSTAS, Laura; Brice H. LAMBERT; Brenda M. BIRMANN; Kirsten B. MOYSICH; Anneclaire J. De ROOS; Jonathan N. HOFMANN; Dalsu BARIS; Sophia S. WANG; Nicola J. CAMP; Guido TRICOT; Djordje ATANACKOVIC; Paul BRENNAN; Pierluigi COCCO; Alexandra NIETERS; Nikolaus BECKER; Marc MAYNADIÉ; Lenka FORETOVÁ; Paolo BOFFETTA; Anthony STAINES; Elisabeth E. BROWN and Silvia de SANJOSÉ. A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiology Biomarkers & Prevention. Philadelphia: American Association for Cancer Research Inc., 2016, vol. 25, No 1, p. 217-221. ISSN 1055-9965. Available from: https://dx.doi.org/10.1158/1055-9965.EPI-15-0953.

@article{1350133,
   author = {Costas, Laura and Lambert, Brice H. and Birmann, Brenda M. and Moysich, Kirsten B. and Roos, Anneclaire J. De and Hofmann, Jonathan N. and Baris, Dalsu and Wang, Sophia S. and Camp, Nicola J. and Tricot, Guido and Atanackovic, Djordje and Brennan, Paul and Cocco, Pierluigi and Nieters, Alexandra and Becker, Nikolaus and Maynadié, Marc and Foretová, Lenka and Boffetta, Paolo and Staines, Anthony and Brown, Elisabeth E. and Sanjosé, Silvia de},
   article_location = {Philadelphia},
   article_number = {1},
   doi = {http://dx.doi.org/10.1158/1055-9965.EPI-15-0953},
   keywords = {LYMPHOMAS; COHORT; HEALTH},
   language = {eng},
   issn = {1055-9965},
   journal = {Cancer Epidemiology Biomarkers & Prevention},
   title = {A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium},
   volume = {25},
   year = {2016}
}

TY  - JOUR
ID  - 1350133
AU  - Costas, Laura - Lambert, Brice H. - Birmann, Brenda M. - Moysich, Kirsten B. - Roos, Anneclaire J. De - Hofmann, Jonathan N. - Baris, Dalsu - Wang, Sophia S. - Camp, Nicola J. - Tricot, Guido - Atanackovic, Djordje - Brennan, Paul - Cocco, Pierluigi - Nieters, Alexandra - Becker, Nikolaus - Maynadié, Marc - Foretová, Lenka - Boffetta, Paolo - Staines, Anthony - Brown, Elisabeth E. - Sanjosé, Silvia de
PY  - 2016
TI  - A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium
JF  - Cancer Epidemiology Biomarkers & Prevention
VL  - 25
IS  - 1
SP  - 217-221
EP  - 217-221
PB  - American Association for Cancer Research Inc.
SN  - 10559965
KW  - LYMPHOMAS
KW  - COHORT
KW  - HEALTH
N2  - Background: Female sex hormones are known to have immunomodulatory effects. Therefore, reproductive factors and exogenous hormone use could influence the risk of multiple myeloma in women. However, the role of hormonal factors in multiple myeloma etiology remains unclear because previous investigations were underpowered to detect modest associations. Methods: We conducted a pooled analysis of seven case-control studies included in the International Multiple Myeloma Consortium, with individual data on reproductive factors and exogenous hormone use from 1,072 female cases and 3,541 female controls. Study-specific odds ratios and corresponding 95% confidence intervals (CI) were estimated using logistic regression and pooled analyses were conducted using random effects meta-analyses. Results: Multiple myeloma was not associated with reproductive factors, including ever parous [OR = 0.92; 95% confidence interval (CI), 0.68-1.25], or with hormonal contraception use (OR = 1.04; 95% CI, 0.80-1.36). Postmenopausal hormone therapy users had nonsignificantly reduced risks of multiple myeloma compared with never users, but this association differed across centers (OR = 0.65; 95% CI, 0.37-1.15, I-2 = 76.0%, P-heterogeneity = 0.01). Conclusions: These data do not support a role for reproductive factors or exogenous hormones in myelomagenesis. Impact: Incidence rates of multiple myeloma are higher in men than in women, and sex hormones could influence this pattern. Associations with reproductive factors and exogenous hormone use were inconclusive despite our large sample size, suggesting that female sex hormones may not play a significant role in multiple myeloma etiology.
ER  -

COSTAS, Laura; Brice H. LAMBERT; Brenda M. BIRMANN; Kirsten B. MOYSICH; Anneclaire J. De ROOS; Jonathan N. HOFMANN; Dalsu BARIS; Sophia S. WANG; Nicola J. CAMP; Guido TRICOT; Djordje ATANACKOVIC; Paul BRENNAN; Pierluigi COCCO; Alexandra NIETERS; Nikolaus BECKER; Marc MAYNADIÉ; Lenka FORETOVÁ; Paolo BOFFETTA; Anthony STAINES; Elisabeth E. BROWN and Silvia de SANJOSÉ. A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. \textit{Cancer Epidemiology Biomarkers \&{} Prevention}. Philadelphia: American Association for Cancer Research Inc., 2016, vol.~25, No~1, p.~217-221. ISSN~1055-9965. Available from: https://dx.doi.org/10.1158/1055-9965.EPI-15-0953.

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