| MARVANOVÁ, Pavlína, Tereza PADRTOVÁ, Tomáš PEKÁREK, Jiří BRUS, Jiří CZERNEK, Petr MOKRÝ, Otakar HUMPA, Michal ORAVEC a Josef JAMPILEK. Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts. Molecules. BASEL: MDPI AG, 2016, roč. 21, č. 6, s. nestránkováno, 13 s. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules21060707. |
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@article{1350890,
author = {Marvanová, Pavlína and Padrtová, Tereza and Pekárek, Tomáš and Brus, Jiří and Czernek, Jiří and Mokrý, Petr and Humpa, Otakar and Oravec, Michal and Jampilek, Josef},
article_location = {BASEL},
article_number = {6},
doi = {http://dx.doi.org/10.3390/molecules21060707},
keywords = {arylcarbonyloxyaminopropanols; phenylpiperazines; synthesis; CP/MASNMR spectroscopy; IR spectroscopy; principle components analysis},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts},
url = {http://www.mdpi.com/1420-3049/21/6/707/htm},
volume = {21},
year = {2016}
}
TY - JOUR
ID - 1350890
AU - Marvanová, Pavlína - Padrtová, Tereza - Pekárek, Tomáš - Brus, Jiří - Czernek, Jiří - Mokrý, Petr - Humpa, Otakar - Oravec, Michal - Jampilek, Josef
PY - 2016
TI - Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts
JF - Molecules
VL - 21
IS - 6
SP - nestránkováno
EP - nestránkováno
PB - MDPI AG
SN - 14203049
KW - arylcarbonyloxyaminopropanols
KW - phenylpiperazines
KW - synthesis
KW - CP/MASNMR spectroscopy
KW - IR spectroscopy
KW - principle components analysis
UR - http://www.mdpi.com/1420-3049/21/6/707/htm
L2 - http://www.mdpi.com/1420-3049/21/6/707/htm
N2 - Five new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates were designed and synthesized as potential dual antihypertensive agents. The compounds were prepared as free bases and subsequently transformed to hydrochloride salts. The position of protonation of nitrogen atoms in the piperazine ring of hydrochloride salts was determined by means of C-13-CP/MAS and N-15-CP/MAS NMR and IR spectroscopy. Using these solid-state analytical techniques, it was found that both nitrogen atoms were protonated when excess hydrogen chloride was used for preparation of salts. On the other hand, when the equimolar amount of hydrogen chloride was used, piperazine nitrogen substituted by aryl was protonated.
ER -
MARVANOVÁ, Pavlína, Tereza PADRTOVÁ, Tomáš PEKÁREK, Jiří BRUS, Jiří CZERNEK, Petr MOKRÝ, Otakar HUMPA, Michal ORAVEC a Josef JAMPILEK. Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts. \textit{Molecules}. BASEL: MDPI AG, 2016, roč.~21, č.~6, s.~nestránkováno, 13 s. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules21060707.
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