Detailed Information on Publication Record
2017
Genetic determinants and postorthodontic external apical root resorption in Czech children
BOŘILOVÁ LINHARTOVÁ, Petra, Pavlína ČERNOCHOVÁ, Jakub KAŠTOVSKÝ, Zuzana VRANKOVÁ, Martina SIROTKOVÁ et. al.Basic information
Original name
Genetic determinants and postorthodontic external apical root resorption in Czech children
Name in Czech
Genetické determinanty a postortodontická zevní apikální resorpce kořene u českých dětí
Authors
BOŘILOVÁ LINHARTOVÁ, Petra (203 Czech Republic, guarantor, belonging to the institution), Pavlína ČERNOCHOVÁ (203 Czech Republic, belonging to the institution), Jakub KAŠTOVSKÝ (203 Czech Republic, belonging to the institution), Zuzana VRANKOVÁ (703 Slovakia, belonging to the institution), Martina SIROTKOVÁ (703 Slovakia, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution)
Edition
Oral Disease, Hoboken, Wiley-Blackwell, 2017, 1354-523X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30208 Dentistry, oral surgery and medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.310
RIV identification code
RIV/00216224:14110/17:00094544
Organization unit
Faculty of Medicine
UT WoS
000390268200007
Keywords (in Czech)
genový polymorfizmus; ortodontická léčba; resorpce kořene
Keywords in English
gene polymorphism; orthodontic treatment; root resorption
Tags
Tags
International impact, Reviewed
Změněno: 20/3/2018 10:12, Soňa Böhmová
V originále
Objective: Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin-17A (IL-17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment. Subjects and Methods: This case–control study comprised 99 orthodontically treated patients (69 controls and 30 subjects with EARR). Genotype determinations of rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, and rs2073618 were based on polymerase chain reaction using 5 nuclease TaqMan® assays. Results: While no significant differences were observed in allele or genotype frequencies of all seven studied SNPs, specific haplotype of P2RX7 (rs208294 and rs1718119) modified the risk of EARR development (P < 0.05). In addition, the length of treatment with a fixed orthodontic appliance positively correlated with the presence of EARR (P < 0.05). Conclusions: Although the effect of individual SNPs studied on the EARR development was not confirmed in the Czech population, complex analysis suggested that variability in the P2RX7 gene and the length of orthodontic treatment may be important factors contributing to the etiopathogenesis of postorthodontic EARR.
In Czech
Cílem studie bylo analyzovat asociace mezi sedmi jednonukleotidovými polymorfizmy (SNPs)v genech pro interleukin-17A (IL-17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7) a člen 11 receptoru pro tumor necrosis faktor superrodiny (TNFRSF11B) a EARR u dětí po ortodontické léčbě.
Links
| GB14-37368G, research and development project |
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| MUNI/A/1258/2015, interní kód MU |
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| ROZV/24/LF/2016, interní kód MU |
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