NEŠPOROVÁ, Kristina, Jana SOGORKOVA, Daniela SMEJKALOVÁ, J. KULHANEK, G. HUERTA-ANGELES, Lukáš KUBALA and Vladimír VELEBNÝ. Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles. International Journal of Pharmaceutics. AMSTERDAM: ELSEVIER SCIENCE BV, 2016, vol. 511, No 1, p. 638-647. ISSN 0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2016.07.057.
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Basic information
Original name Influence of serum albumin on intracellular delivery of drug-loaded hyaluronan polymeric micelles
Authors NEŠPOROVÁ, Kristina (203 Czech Republic, belonging to the institution), Jana SOGORKOVA (203 Czech Republic), Daniela SMEJKALOVÁ (203 Czech Republic, guarantor), J. KULHANEK (203 Czech Republic), G. HUERTA-ANGELES (484 Mexico), Lukáš KUBALA (203 Czech Republic, belonging to the institution) and Vladimír VELEBNÝ (203 Czech Republic).
Edition International Journal of Pharmaceutics, AMSTERDAM, ELSEVIER SCIENCE BV, 2016, 0378-5173.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.649
RIV identification code RIV/00216224:14310/16:00095864
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.ijpharm.2016.07.057
UT WoS 000382263700065
Keywords in English Polymeric micelle; Hyaluronan; Fatty acid; Albumin; Cell uptake; Stability
Tags NZ, rivok
Tags International impact, Reviewed
Changed by Changed by: Ing. Nicole Zrilić, učo 240776. Changed: 13/4/2018 14:15.
Abstract
Polymeric micelles are attractive drug delivery systems for intravenously administered nonpolar drugs. Although physical parameters like size, shape and loading capacity are considered as the most important for their efficiency, here we demonstrate that the effects of serum protein interaction and characteristics of loaded compound cannot be neglected during the micelle development and design of experimental set up. Polymeric micelles prepared from amphiphilic hyaluronic acid grafted with short (hexanoic) and long fatty acids (oleic) were tested after loading with two different hydrophobic models, Nile red and curcumin. The composition of micelles affected mainly the loading capacity. Both encapsulated compounds behaved differently in the in vitro cell uptake, which was also influenced by serum concentration, where serum albumin was found to be the primary destabilizing component. This destabilization was found to be influenced by polymeric micelle concentration. Thus, the chemical structure of micelle, the properties of non-covalently loaded substance and serum albumin/polymeric micelle ratio modulate the in vitro intracellular uptake of drugs loaded in nanocarriers. (C) 2016 Published by Elsevier B.V.
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