LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA, M.P. MOYER, J. EHRMANN a A.H. VACULOVA. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. Plos one. San Francisco: Public Library of Science, 2015, roč. 10, č. 10, s. nestránkováno, 20 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0141020. |
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@article{1351865, author = {Lauková, Jarmila and Kozubík, Alois and Hofmanová, Jiřina and Nekvindová, Jana and Sova, P. and Moyer, M.P. and Ehrmann, J. and Vaculova, A.H.}, article_location = {San Francisco}, article_number = {10}, doi = {http://dx.doi.org/10.1371/journal.pone.0141020}, keywords = {ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; ANTITUMOR EFFICACY; DNA-DAMAGE; IN-VITRO; CISPLATIN; LA-12; INHIBITION; GROWTH; ADAMANTYLAMINE}, language = {eng}, issn = {1932-6203}, journal = {Plos one}, title = {Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells}, url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020}, volume = {10}, year = {2015} }
TY - JOUR ID - 1351865 AU - Lauková, Jarmila - Kozubík, Alois - Hofmanová, Jiřina - Nekvindová, Jana - Sova, P. - Moyer, M.P. - Ehrmann, J. - Vaculova, A.H. PY - 2015 TI - Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells JF - Plos one VL - 10 IS - 10 SP - nestránkováno EP - nestránkováno PB - Public Library of Science SN - 19326203 KW - ACTIVATED-RECEPTOR-GAMMA KW - PPAR-GAMMA KW - ANTITUMOR EFFICACY KW - DNA-DAMAGE KW - IN-VITRO KW - CISPLATIN KW - LA-12 KW - INHIBITION KW - GROWTH KW - ADAMANTYLAMINE UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020 L2 - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020 N2 - We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPAR. proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function. ER -
LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA, M.P. MOYER, J. EHRMANN a A.H. VACULOVA. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. \textit{Plos one}. San Francisco: Public Library of Science, 2015, roč.~10, č.~10, s.~nestránkováno, 20 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0141020.
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