Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of
Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer
Cells

J 2015

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA et. al.

Základní údaje

Originální název

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

Autoři

LAUKOVÁ, Jarmila (703 Slovensko, domácí), Alois KOZUBÍK (203 Česká republika, domácí), Jiřina HOFMANOVÁ (203 Česká republika, domácí), Jana NEKVINDOVÁ (203 Česká republika), P. SOVA (203 Česká republika), M.P. MOYER (840 Spojené státy), J. EHRMANN (203 Česká republika) a A.H. VACULOVA (203 Česká republika, garant)

Vydání

Plos one, San Francisco, Public Library of Science, 2015, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.057

Kód RIV

RIV/00216224:14310/15:00095868

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0141020

UT WoS

000363249300023

Klíčová slova anglicky

ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; ANTITUMOR EFFICACY; DNA-DAMAGE; IN-VITRO; CISPLATIN; LA-12; INHIBITION; GROWTH; ADAMANTYLAMINE

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 4. 2018 15:47, Ing. Nicole Zrilić

Anotace

V originále

We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPAR. proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.

Citovat

LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA, M.P. MOYER, J. EHRMANN a A.H. VACULOVA. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. Plos one. San Francisco: Public Library of Science, 2015, roč. 10, č. 10, s. nestránkováno, 20 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0141020.

@article{1351865,
   author = {Lauková, Jarmila and Kozubík, Alois and Hofmanová, Jiřina and Nekvindová, Jana and Sova, P. and Moyer, M.P. and Ehrmann, J. and Vaculova, A.H.},
   article_location = {San Francisco},
   article_number = {10},
   doi = {http://dx.doi.org/10.1371/journal.pone.0141020},
   keywords = {ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; ANTITUMOR EFFICACY; DNA-DAMAGE; IN-VITRO; CISPLATIN; LA-12; INHIBITION; GROWTH; ADAMANTYLAMINE},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells},
   url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1351865
AU  - Lauková, Jarmila - Kozubík, Alois - Hofmanová, Jiřina - Nekvindová, Jana - Sova, P. - Moyer, M.P. - Ehrmann, J. - Vaculova, A.H.
PY  - 2015
TI  - Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells
JF  - Plos one
VL  - 10
IS  - 10
SP  - nestránkováno
EP  - nestránkováno
PB  - Public Library of Science
SN  - 19326203
KW  - ACTIVATED-RECEPTOR-GAMMA
KW  - PPAR-GAMMA
KW  - ANTITUMOR EFFICACY
KW  - DNA-DAMAGE
KW  - IN-VITRO
KW  - CISPLATIN
KW  - LA-12
KW  - INHIBITION
KW  - GROWTH
KW  - ADAMANTYLAMINE
UR  - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020
L2  - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141020
N2  - We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPAR. proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.
ER  -

LAUKOVÁ, Jarmila, Alois KOZUBÍK, Jiřina HOFMANOVÁ, Jana NEKVINDOVÁ, P. SOVA, M.P. MOYER, J. EHRMANN a A.H. VACULOVA. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. \textit{Plos one}. San Francisco: Public Library of Science, 2015, roč.~10, č.~10, s.~nestránkováno, 20 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0141020.

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