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@article{1352757, author = {Mikulášová, Aneta and Smetana, Jan and Wayhelová, Markéta and Janyšková, Helena and Sandecká, Viera and Kufová, Zuzana and Almáši, Martina and Jarkovský, Jiří and Gregora, Evzen and Kessler, Petr and Wrobel, Marek and Walker, Brian and Wardell, Christopher and Morgan, Gareth and Hájek, Roman and Kuglík, Petr}, article_number = {6}, doi = {http://dx.doi.org/10.1111/ejh.12774}, keywords = {DNA copy-number changes; DNA microarrays; monoclonal gammopathies; prognosis}, language = {eng}, issn = {0902-4441}, journal = {European Journal of Haematology}, title = {Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance}, url = {http://onlinelibrary.wiley.com/doi/10.1111/ejh.12774/full}, volume = {97}, year = {2016} }
TY - JOUR ID - 1352757 AU - Mikulášová, Aneta - Smetana, Jan - Wayhelová, Markéta - Janyšková, Helena - Sandecká, Viera - Kufová, Zuzana - Almáši, Martina - Jarkovský, Jiří - Gregora, Evzen - Kessler, Petr - Wrobel, Marek - Walker, Brian - Wardell, Christopher - Morgan, Gareth - Hájek, Roman - Kuglík, Petr PY - 2016 TI - Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance JF - European Journal of Haematology VL - 97 IS - 6 SP - 568-575 EP - 568-575 PB - Wiley-Blackwell Munksgaard SN - 09024441 KW - DNA copy-number changes KW - DNA microarrays KW - monoclonal gammopathies KW - prognosis UR - http://onlinelibrary.wiley.com/doi/10.1111/ejh.12774/full N2 - Monoclonal gammopathy of undetermined significance (MGUS) is a benign condition with an approximate 1% annual risk of symptomatic plasma cell disorder development, mostly to multiple myeloma (MM). We performed genome-wide screening of copy-number alterations (CNAs) in 90 MGUS and 33 MM patients using high-density DNA microarrays. We identified CNAs in a smaller proportion of MGUS (65.6%) than in MM (100.0%, p=1.31×10-5 ) and showed median number of CNAs is lower in MGUS (3, range 0-22) than in MM (13, range 4-38, p=1.82×10-10 ). In the MGUS cohort, the most frequent losses were located at 1p (5.6%), 6q (6.7%), 13q (30.0%), 14q (14.4%), 16q (8.9%), 21q (5.6%) and gains at 1q (23.3%), 2p (6.7%), 6p (13.3%) and Xq (7.8%). Hyperdiploidy was detected in 38.9% of MGUS cases and the most frequent whole chromosome gains were 3 (25.6%), 5 (23.3%), 9 (37.8%), 15 (23.3%) and 19 (32.2%). We also identified CNAs such as 1p, 6q, 8p, 12p, 13q, 16q losses, 1q gain and hypodiploidy, which are potentially associated with an adverse prognosis in MGUS. In summary, we showed that MGUS is similar to MM in that it is a genetically heterogeneous disorder, but overall cytogenetic instability is lower than in MM, which confirms that genetic abnormalities play important role in monoclonal gammopathies. ER -
MIKULÁŠOVÁ, Aneta, Jan SMETANA, Markéta WAYHELOVÁ, Helena JANYŠKOVÁ, Viera SANDECKÁ, Zuzana KUFOVÁ, Martina ALMÁŠI, Jiří JARKOVSKÝ, Evzen GREGORA, Petr KESSLER, Marek WROBEL, Brian WALKER, Christopher WARDELL, Gareth MORGAN, Roman HÁJEK a Petr KUGLÍK. Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance. \textit{European Journal of Haematology}. Wiley-Blackwell Munksgaard, 2016, roč.~97, č.~6, s.~568-575. ISSN~0902-4441. Dostupné z: https://dx.doi.org/10.1111/ejh.12774.
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