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@article{1353337,
author = {Slama, Jiri and Cerny, Andrej and Dušek, Ladislav and Fischerova, Daniela and Zikan, Michal and Kocian, Roman and Germanova, Anna and Cibula, David},
article_location = {San Diego},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.ygyno.2016.07.008},
keywords = {Cervical cancer; Fertility-sparing surgery; Trachelectomy; Conization},
language = {eng},
issn = {0090-8258},
journal = {Gynecologic Oncology},
title = {Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience},
volume = {142},
year = {2016}
}
TY - JOUR
ID - 1353337
AU - Slama, Jiri - Cerny, Andrej - Dušek, Ladislav - Fischerova, Daniela - Zikan, Michal - Kocian, Roman - Germanova, Anna - Cibula, David
PY - 2016
TI - Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience
JF - Gynecologic Oncology
VL - 142
IS - 3
SP - 401-404
EP - 401-404
PB - Academic Press Inc.
SN - 00908258
KW - Cervical cancer
KW - Fertility-sparing surgery
KW - Trachelectomy
KW - Conization
N2 - Objective. The aim of our study was to describe oncological and obstetrical outcomes in patients who underwent less radical fertility-sparing surgical (FSS) procedureswith omitted parametrectomy for cervical cancer. Methods. Included were women with cervical cancer stages IA2–IB2 who were under the age of 40 and desired future pregnancy. Patients underwent pelvic lymphadenectomy and sentinel lymph node biopsy. Nodenegative cases underwent subsequent cervical surgery and were further analyzed. Neoadjuvant chemotherapy (NAC) was administered in patientswith tumors N2 cmand/or involving N2/3 of cervical stroma. Simple vaginal trachelectomy or needle conization were performed according to tumor extent and topography. The follow-up period started once free surgical margins were reached. Results. Out of 44 women enrolled, 32 women (IA2=7, IB1=23, IB2=2) successfully completed FSS. NAC was administered in 9 (28.1%) cases. A simple trachelectomywas performed in 11 patients and needle conization in 21 patients. During the follow-up, 6 out of 32 women became pregnant. Of these, 1 miscarried and 5 successfully delivered. Disease recurred in 6 patients; 5 recurrenceswere central and 1 recurrence presented as an ovarian mass. Invasive cervical carcinoma, high-grade squamous intraepithelial (HSIL), and low-grade squamous intraepithelial (LSIL) lesions were detected in 4, 1 and 1 patients, respectively. Three of them received NAC. All events were detected within 16 months after surgery. Conclusions. Nearly 27% of patients cannot complete FSS due to node positivity, progression during NAC, or involved margins. The total recurrence rate reached 18.8%, with the majority of invasive recurrences detected in patients after NAC followed by FSS. These patients represent cases at a higher risk of recurrence even if adequate freemargins are reached by surgery. Nearly half of the cohort did not consider pregnancy in the near future because of personal reasons.
ER -
SLAMA, Jiri, Andrej CERNY, Ladislav DUŠEK, Daniela FISCHEROVA, Michal ZIKAN, Roman KOCIAN, Anna GERMANOVA a David CIBULA. Results of less radical fertility-sparing procedures with omitted parametrectomy for cervical cancer: 5 years of experience. \textit{Gynecologic Oncology}. San Diego: Academic Press Inc., 2016, roč.~142, č.~3, s.~401-404. ISSN~0090-8258. Dostupné z: https://dx.doi.org/10.1016/j.ygyno.2016.07.008.
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