Structural Aspects of Multistep Phosphorelay-Mediated Signaling
in Plants

J 2016

Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants

PEKÁROVÁ, Blanka, Agnieszka SZMITKOWSKA, Radka DOPITOVÁ, Oksana DEGTJARIK, Lukáš ŽÍDEK et. al.

Základní údaje

Originální název

Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants

Autoři

PEKÁROVÁ, Blanka (203 Česká republika, domácí), Agnieszka SZMITKOWSKA (616 Polsko, domácí), Radka DOPITOVÁ (203 Česká republika, domácí), Oksana DEGTJARIK (112 Bělorusko), Lukáš ŽÍDEK (203 Česká republika, domácí) a Jan HEJÁTKO (203 Česká republika, garant, domácí)

Vydání

Molecular Plant, Cambridge (USA), Cell Press, 2016, 1674-2052

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.827

Kód RIV

RIV/00216224:14740/16:00088179

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.molp.2015.11.008

UT WoS

000367818800009

Klíčová slova anglicky

multistep phosphorelay; structure; histidine kinase; phosphotransfer protein; response regulator

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 4. 2017 16:01, Mgr. Eva Špillingová

Anotace

V originále

The multistep phosphorelay (MSP) is a central signaling pathway in plants integrating a wide spectrum of hormonal and environmental inputs and controlling numerous developmental adaptations. For the thorough comprehension of the molecular mechanisms underlying the MSP-mediated signal recognition and transduction, the detailed structural characterization of individual members of the pathway is critical. In this review we describe and discuss the recently known crystal and nuclear magnetic resonance structures of proteins acting in MSP signaling in higher plants, focusing particularly on cytokinin and ethylene signaling in Arabidopsis thaliana. We discuss the range of functional aspects of available structural information including determination of ligand specificity, activation of the receptor via its autophosphorylation, and downstreamsignal transduction through the phosphorelay. We compare the plant structures with their bacterial counterparts and show that although the overall similarity is high, the differences in structural details are frequent and functionally important. Finally, we discuss emerging knowledge on molecular recognition mechanisms in the MSP, and mention the latest findings regarding structural determinants of signaling specificity in the Arabidopsis MSP that could serve as a general model of this pathway in all higher plants.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP305/11/0756, projekt VaV

Název: Strukturní princip specificity přenosu signálu v rostlinách: síť interakcí příjímačové domény histidinkinas u Arabidospis (Akronym: HKRD-AHP)

Investor: Grantová agentura ČR, Strukturní princip specificity přenosu signálu v rostlinách: síť interakcí příjímačové domény histidinkinas u Arabidospis

GA13-25280S, projekt VaV

Název: Elucidating molecular mechanisms of cytokinins-ethylene crosstalk in the plant development

Investor: Grantová agentura ČR, Elucidating molecular mechanisms of cytokinins-ethylene crosstalk in the plant development

Citovat

PEKÁROVÁ, Blanka, Agnieszka SZMITKOWSKA, Radka DOPITOVÁ, Oksana DEGTJARIK, Lukáš ŽÍDEK a Jan HEJÁTKO. Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants. Molecular Plant. Cambridge (USA): Cell Press, 2016, roč. 9, č. 1, s. 71-85. ISSN 1674-2052. Dostupné z: https://dx.doi.org/10.1016/j.molp.2015.11.008.

@article{1354811,
   author = {Pekárová, Blanka and Szmitkowska, Agnieszka and Dopitová, Radka and Degtjarik, Oksana and Žídek, Lukáš and Hejátko, Jan},
   article_location = {Cambridge (USA)},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.molp.2015.11.008},
   keywords = {multistep phosphorelay; structure; histidine kinase; phosphotransfer protein; response regulator},
   language = {eng},
   issn = {1674-2052},
   journal = {Molecular Plant},
   title = {Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants},
   url = {http://www.sciencedirect.com/science/article/pii/S1674205215004517},
   volume = {9},
   year = {2016}
}

TY  - JOUR
ID  - 1354811
AU  - Pekárová, Blanka - Szmitkowska, Agnieszka - Dopitová, Radka - Degtjarik, Oksana - Žídek, Lukáš - Hejátko, Jan
PY  - 2016
TI  - Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants
JF  - Molecular Plant
VL  - 9
IS  - 1
SP  - 71-85
EP  - 71-85
PB  - Cell Press
SN  - 16742052
KW  - multistep phosphorelay
KW  - structure
KW  - histidine kinase
KW  - phosphotransfer protein
KW  - response regulator
UR  - http://www.sciencedirect.com/science/article/pii/S1674205215004517
L2  - http://www.sciencedirect.com/science/article/pii/S1674205215004517
N2  - The multistep phosphorelay (MSP) is a central signaling pathway in plants integrating a wide spectrum of hormonal and environmental inputs and controlling numerous developmental adaptations. For the thorough comprehension of the molecular mechanisms underlying the MSP-mediated signal recognition and transduction, the detailed structural characterization of individual members of the pathway is critical. In this review we describe and discuss the recently known crystal and nuclear magnetic resonance structures of proteins acting in MSP signaling in higher plants, focusing particularly on cytokinin and ethylene signaling in Arabidopsis thaliana. We discuss the range of functional aspects of available structural information including determination of ligand specificity, activation of the receptor via its autophosphorylation, and downstreamsignal transduction through the phosphorelay. We compare the plant structures with their bacterial counterparts and show that although the overall similarity is high, the differences in structural details are frequent and functionally important. Finally, we discuss emerging knowledge on molecular recognition mechanisms in the MSP, and mention the latest findings regarding structural determinants of signaling specificity in the Arabidopsis MSP that could serve as a general model of this pathway in all higher plants.
ER  -

PEKÁROVÁ, Blanka, Agnieszka SZMITKOWSKA, Radka DOPITOVÁ, Oksana DEGTJARIK, Lukáš ŽÍDEK a Jan HEJÁTKO. Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants. \textit{Molecular Plant}. Cambridge (USA): Cell Press, 2016, roč.~9, č.~1, s.~71-85. ISSN~1674-2052. Dostupné z: https://dx.doi.org/10.1016/j.molp.2015.11.008.

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