2016
Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
HÝŽA, Martin, Matyáš KUHN, Eva ČEŠKOVÁ, Libor USTOHAL, Tomáš KAŠPÁREK et. al.Základní údaje
Originální název
Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
Autoři
HÝŽA, Martin (203 Česká republika, garant, domácí), Matyáš KUHN (203 Česká republika, domácí), Eva ČEŠKOVÁ (203 Česká republika, domácí), Libor USTOHAL (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, domácí)
Vydání
World Journal of Biological Psychiatry, Abingdon, Taylor & Francis LTD, 2016, 1562-2975
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 3.658
Kód RIV
RIV/00216224:14110/16:00091001
Organizační jednotka
Lékařská fakulta
UT WoS
000383408000003
Klíčová slova anglicky
atrophy; hippocampus; predisposition; Schizophrenia; toxicity
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 24. 10. 2016 15:20, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
Objectives: Several lines of evidence suggest an adverse effect of psychotic episodes on brain morphology. It is not clear if this relationship reflects the cumulative effect of psychotic outbursts on the gradual progressive reduction of hippocampal tissue or an increased tendency toward psychotic episodes in patients with a smaller hippocampus at the beginning of the illness. Methods: This is a longitudinal 4-year prospective study of patients with first-episode schizophrenia (FES, N = 58). Baseline brain anatomical scans (at FES) were analysed using voxel-based morphometry and atlas-based volumetry of the hippocampal subfields. The effects of first-episode duration on the hippocampal morphology, and the effect of baseline hippocampal morphology on illness course with relapses, number of psychotic episodes and residual symptoms were analysed. Results: A significant negative correlation was detected between first-episode duration and baseline hippocampal morphology. Relapse, number of psychotic episodes and residual symptoms had no correlation with baseline hippocampal volume. Conclusions: We replicated the effect of psychosis duration on hippocampal volume already at the time first-episode, which supports the concept of toxicity of psychosis. The indices of a later unfavourable course of schizophrenia had no correlation with baseline brain morphology, suggesting that there is no baseline morphological abnormality of the hippocampus that predisposes the patient to frequent psychotic outbursts.
Návaznosti
| ED1.1.00/02.0068, projekt VaV |
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