| KUCČEROVÁ, Pavla, Jana SKOPALOVÁ, Lukáš KUČERA, Jan HRBÁČ a Karel LEMR. Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry. Electrochimica Acta. OXFORD: Elsevier, 2015, roč. 159, MARCH, s. 131-139. ISSN 0013-4686. Dostupné z: https://dx.doi.org/10.1016/j.electacta.2015.01.190. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1355817,
author = {Kucčerová, Pavla and Skopalová, Jana and Kučera, Lukáš and Hrbáč, Jan and Lemr, Karel},
article_location = {OXFORD},
article_number = {MARCH},
doi = {http://dx.doi.org/10.1016/j.electacta.2015.01.190},
keywords = {Fesoterodine; Oxidation; Hydrolysis; Voltammetry; Mass spectrometry},
language = {eng},
issn = {0013-4686},
journal = {Electrochimica Acta},
title = {Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry},
volume = {159},
year = {2015}
}
TY - JOUR
ID - 1355817
AU - Kucčerová, Pavla - Skopalová, Jana - Kučera, Lukáš - Hrbáč, Jan - Lemr, Karel
PY - 2015
TI - Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry
JF - Electrochimica Acta
VL - 159
IS - MARCH
SP - 131-139
EP - 131-139
PB - Elsevier
SN - 00134686
KW - Fesoterodine
KW - Oxidation
KW - Hydrolysis
KW - Voltammetry
KW - Mass spectrometry
N2 - The electrochemical behavior of fesoterodine (FES), an antimuscarinic drug used for the treatment of urge incontinence and overactive bladder, was investigated using linear sweep and cyclic voltammetry at a stationary and rotating disc glassy carbon electrodes. A single two-electron anodic signal of FES was observed in neutral buffered aqueous methanolic solutions. Kinetics of alkaline hydrolysis of FES to its active metabolite 5-hydroxymethyl tolterodine was investigated by time dependent linear sweep voltammetry. Controlled potential electrolysis of FES solutions was performed at platinum gauze electrode in aqueous-methanolic media. Electrolyzed solutions were analyzed using ultra performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. Two main products of electrochemical oxidation of fesoterodine were identified as 5-formyl fesoterodine (isobutyric acid 2-(3-diisopropylamino-1-phenyl-propyl)-4-formyl-phenyl ester) and N-desisopropylated fesoterodine (isobutyric acid 4-hydroxymethyl-2-(3-isopropylamino-1-phenyl-propyl)-phenyl ester). The mechanism of the electrochemical oxidation of FES has been proposed and confirmed using on-line electrochemistry/mass spectrometry with porous glassy carbon electrode. (C) 2015 Elsevier Ltd. All rights reserved.
ER -
KUCČEROVÁ, Pavla, Jana SKOPALOVÁ, Lukáš KUČERA, Jan HRBÁČ a Karel LEMR. Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry. \textit{Electrochimica Acta}. OXFORD: Elsevier, 2015, roč.~159, MARCH, s.~131-139. ISSN~0013-4686. Dostupné z: https://dx.doi.org/10.1016/j.electacta.2015.01.190.
|
