Electrochemical sensing of etoposide using carbon quantum dot
modified glassy carbon electrode

J 2016

Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode

NGUYEN, Hoai Viet, Lukas RICHTERA, Amitava MOULICK, Kledi XHAXHIU, Jiri KUDR et. al.

Základní údaje

Originální název

Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode

Autoři

NGUYEN, Hoai Viet (203 Česká republika), Lukas RICHTERA (203 Česká republika), Amitava MOULICK (203 Česká republika), Kledi XHAXHIU (8 Albánie), Jiri KUDR (203 Česká republika), Natalia CERNEI (203 Česká republika), Hana POLANSKÁ (203 Česká republika, domácí), Zbynek HEGER (203 Česká republika), Michal MASAŘÍK (203 Česká republika, garant, domácí), Pavel KOPEL (203 Česká republika), Marie STIBOROVA (203 Česká republika), Tomas ECKSCHLAGER (203 Česká republika), Vojtech ADAM (203 Česká republika) a Rene KIZEK (616 Polsko)

Vydání

Analyst, Cambridge, The Royal Society of Chemistry, 2016, 0003-2654

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.885

Kód RIV

RIV/00216224:14110/16:00091188

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1039/c5an02476e

UT WoS

000374957000006

Klíčová slova anglicky

PERFORMANCE LIQUID-CHROMATOGRAPHY; DNA TOPOISOMERASE-II; HUMAN PLASMA; CATECHOL METABOLITE; EMERGENT NANOLIGHTS; ANTITUMOR AGENTS; VP 16-213; NANOPARTICLES; DRUGS; CELLS

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 10. 2016 12:17, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

In this study, enhancement of the electrochemical signals of etoposide (ETO) measured by differential pulse voltammetry (DPV) by modifying a glassy carbon electrode (GCE) with carbon quantum dots (CQDs) is demonstrated. In comparison with a bare GCE, the modified GCE exhibited a higher sensitivity towards electrochemical detection of ETO. The lowest limit of detection was observed to be 5 nM ETO. Furthermore, scanning electron microscopy (SEM), fluorescence microscopy (FM), and electrochemical impedance spectroscopy (EIS) were employed for the further study of the working electrode surface after the modification with CQDs. Finally, the GCE modified with CQDs under optimized conditions was used to analyse real samples of ETO in the prostate cancer cell line PC3. After different incubation times (1, 3, 6, 9, 12, 18 and 24 h), these samples were then prepared prior to electrochemical detection by the GCE modified with CQDs. High performance liquid chromatography with an electrochemical detection method was employed to verify the results from the GCE modified with CQDs.

Citovat

NGUYEN, Hoai Viet, Lukas RICHTERA, Amitava MOULICK, Kledi XHAXHIU, Jiri KUDR, Natalia CERNEI, Hana POLANSKÁ, Zbynek HEGER, Michal MASAŘÍK, Pavel KOPEL, Marie STIBOROVA, Tomas ECKSCHLAGER, Vojtech ADAM a Rene KIZEK. Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode. Analyst. Cambridge: The Royal Society of Chemistry, 2016, roč. 141, č. 9, s. 2665-2675. ISSN 0003-2654. Dostupné z: https://dx.doi.org/10.1039/c5an02476e.

@article{1356671,
   author = {Nguyen, Hoai Viet and Richtera, Lukas and Moulick, Amitava and Xhaxhiu, Kledi and Kudr, Jiri and Cernei, Natalia and Polanská, Hana and Heger, Zbynek and Masařík, Michal and Kopel, Pavel and Stiborova, Marie and Eckschlager, Tomas and Adam, Vojtech and Kizek, Rene},
   article_location = {Cambridge},
   article_number = {9},
   doi = {http://dx.doi.org/10.1039/c5an02476e},
   keywords = {PERFORMANCE LIQUID-CHROMATOGRAPHY; DNA TOPOISOMERASE-II; HUMAN PLASMA; CATECHOL METABOLITE; EMERGENT NANOLIGHTS; ANTITUMOR AGENTS; VP 16-213; NANOPARTICLES; DRUGS; CELLS},
   language = {eng},
   issn = {0003-2654},
   journal = {Analyst},
   title = {Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode},
   volume = {141},
   year = {2016}
}

TY  - JOUR
ID  - 1356671
AU  - Nguyen, Hoai Viet - Richtera, Lukas - Moulick, Amitava - Xhaxhiu, Kledi - Kudr, Jiri - Cernei, Natalia - Polanská, Hana - Heger, Zbynek - Masařík, Michal - Kopel, Pavel - Stiborova, Marie - Eckschlager, Tomas - Adam, Vojtech - Kizek, Rene
PY  - 2016
TI  - Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode
JF  - Analyst
VL  - 141
IS  - 9
SP  - 2665-2675
EP  - 2665-2675
PB  - The Royal Society of Chemistry
SN  - 00032654
KW  - PERFORMANCE LIQUID-CHROMATOGRAPHY
KW  - DNA TOPOISOMERASE-II
KW  - HUMAN PLASMA
KW  - CATECHOL METABOLITE
KW  - EMERGENT NANOLIGHTS
KW  - ANTITUMOR AGENTS
KW  - VP 16-213
KW  - NANOPARTICLES
KW  - DRUGS
KW  - CELLS
N2  - In this study, enhancement of the electrochemical signals of etoposide (ETO) measured by differential pulse voltammetry (DPV) by modifying a glassy carbon electrode (GCE) with carbon quantum dots (CQDs) is demonstrated. In comparison with a bare GCE, the modified GCE exhibited a higher sensitivity towards electrochemical detection of ETO. The lowest limit of detection was observed to be 5 nM ETO. Furthermore, scanning electron microscopy (SEM), fluorescence microscopy (FM), and electrochemical impedance spectroscopy (EIS) were employed for the further study of the working electrode surface after the modification with CQDs. Finally, the GCE modified with CQDs under optimized conditions was used to analyse real samples of ETO in the prostate cancer cell line PC3. After different incubation times (1, 3, 6, 9, 12, 18 and 24 h), these samples were then prepared prior to electrochemical detection by the GCE modified with CQDs. High performance liquid chromatography with an electrochemical detection method was employed to verify the results from the GCE modified with CQDs.
ER  -

NGUYEN, Hoai Viet, Lukas RICHTERA, Amitava MOULICK, Kledi XHAXHIU, Jiri KUDR, Natalia CERNEI, Hana POLANSKÁ, Zbynek HEGER, Michal MASAŘÍK, Pavel KOPEL, Marie STIBOROVA, Tomas ECKSCHLAGER, Vojtech ADAM a Rene KIZEK. Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode. \textit{Analyst}. Cambridge: The Royal Society of Chemistry, 2016, roč.~141, č.~9, s.~2665-2675. ISSN~0003-2654. Dostupné z: https://dx.doi.org/10.1039/c5an02476e.

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