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@article{1356688,
author = {Polanská, Hana and Raudenská, Martina and Hudcová, Kristýna and Gumulec, Jaromír and Svobodová, Markéta and Heger, Zbynek and Fojtů, Michaela and Binková, Hana and Horáková, Zuzana and Kostřica, Rom and Adam, Vojtech and Kizek, Rene and Masařík, Michal},
article_location = {Athens},
article_number = {3},
keywords = {spinocellular cancer; biomarker; EGFR; head and neck tumors; plasma; diagnosis},
language = {eng},
issn = {1792-1074},
journal = {Oncology letters},
title = {Evaluation of EGFR as a prognostic and diagnostic marker for head and neck squamous cell carcinoma patients},
volume = {12},
year = {2016}
}
TY - JOUR
ID - 1356688
AU - Polanská, Hana - Raudenská, Martina - Hudcová, Kristýna - Gumulec, Jaromír - Svobodová, Markéta - Heger, Zbynek - Fojtů, Michaela - Binková, Hana - Horáková, Zuzana - Kostřica, Rom - Adam, Vojtech - Kizek, Rene - Masařík, Michal
PY - 2016
TI - Evaluation of EGFR as a prognostic and diagnostic marker for head and neck squamous cell carcinoma patients
JF - Oncology letters
VL - 12
IS - 3
SP - 2127-2132
EP - 2127-2132
PB - Spandidos Publications
SN - 17921074
KW - spinocellular cancer
KW - biomarker
KW - EGFR
KW - head and neck tumors
KW - plasma
KW - diagnosis
N2 - Approximately 90% of all head and neck tumors are squamous cell carcinomas. The overall survival of patients with head and neck squamous cell carcinoma (HNSCC) is low (<= 50%). A non-invasive marker of disease progression is sorely required. The present study focused on the plasmatic levels of epidermal growth factor receptor (EGFR) in HNSCC patients (N=92) compared with healthy (N=29) and diabetic [type 2 diabetes mellitus (T2DM); N=26] controls. Enzyme-linked immunosorbent assay using antibodies against the extracellular region of EGFR (L25-S645) was performed. No significant changes were observed between diabetic and healthy controls. However, there were significantly higher EGFR plasma levels in HNSCC patients compared with both control groups (P=0.001 and 0.005, respectively). Receiver operating characteristic curve analysis identified a sensitivity of 76.09%, a specificity of 67.27% and an area under curve of 0.727 for this comparison. No significant association was observed between EGFR plasma levels and tumor stage, tumor grade, lymph node or distant metastasis occurrence, smoking habit or hypertension. However, the presence of human papillomavirus infection and T2DM in HNSCC patients had borderline effect on the plasma EGFR levels. Survival analysis revealed no significant influence of plasmatic EGFR levels on the overall and disease-specific survival of HNSCC patients. In conclusion, EGFR plasma levels appear to be a relatively promising diagnostic, but poor prognostic, HNSCC marker.
ER -
POLANSKÁ, Hana, Martina RAUDENSKÁ, Kristýna HUDCOVÁ, Jaromír GUMULEC, Markéta SVOBODOVÁ, Zbynek HEGER, Michaela FOJTŮ, Hana BINKOVÁ, Zuzana HORÁKOVÁ, Rom KOSTŘICA, Vojtech ADAM, Rene KIZEK a Michal MASAŘÍK. Evaluation of EGFR as a prognostic and diagnostic marker for head and neck squamous cell carcinoma patients. \textit{Oncology letters}. Athens: Spandidos Publications, 2016, roč.~12, č.~3, s.~2127-2132. ISSN~1792-1074.
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