Effect of HPV on tumor expression levels of the most commonly
used markers in HNSCC

J 2016

Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

POLANSKÁ, Hana, Zbynek HEGER, Jaromír GUMULEC, Martina RAUDENSKÁ, Markéta SVOBODOVÁ et. al.

Basic information

Original name

Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

Authors

POLANSKÁ, Hana (203 Czech Republic, belonging to the institution), Zbynek HEGER (203 Czech Republic), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution), Markéta SVOBODOVÁ (203 Czech Republic, belonging to the institution), Jan BALVAN (203 Czech Republic, belonging to the institution), Michaela FOJTŮ (203 Czech Republic, belonging to the institution), Hana BINKOVÁ (203 Czech Republic), Zuzana HORÁKOVÁ (203 Czech Republic), Rom KOSTŘICA (203 Czech Republic), Vojtech ADAM (203 Czech Republic), Rene KIZEK (203 Czech Republic) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Tumor Biology, Dordrecht, Springer, 2016, 1010-4283

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.650

RIV identification code

RIV/00216224:14110/16:00088890

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s13277-015-4569-6

UT WoS

000376464700018

Keywords in English

Head and neck cancer; Human papillomavirus; Tumor markers; Kaplan-Meier analysis

Abstract

V originále

Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.

Links

MUNI/A/1326/2014, interní kód MU

Name: Kardiovaskulární systém od buňky k lůžku pacienta (Acronym: KASBUNPAC)

Investor: Masaryk University, Category A

MUNI/A/1549/2014, interní kód MU

Name: Experimentální molekulární patofyziologie vybraných komplexních chorob/ stavů (Acronym: markery komplexních nemocí)

Investor: Masaryk University, Category A

NT14337, research and development project

Name: Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.

Investor: Ministry of Health of the CR

Citovat

POLANSKÁ, Hana, Zbynek HEGER, Jaromír GUMULEC, Martina RAUDENSKÁ, Markéta SVOBODOVÁ, Jan BALVAN, Michaela FOJTŮ, Hana BINKOVÁ, Zuzana HORÁKOVÁ, Rom KOSTŘICA, Vojtech ADAM, Rene KIZEK and Michal MASAŘÍK. Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC. Tumor Biology. Dordrecht: Springer, 2016, vol. 37, No 6, p. 7193-7201. ISSN 1010-4283. Available from: https://dx.doi.org/10.1007/s13277-015-4569-6.

@article{1356689,
   author = {Polanská, Hana and Heger, Zbynek and Gumulec, Jaromír and Raudenská, Martina and Svobodová, Markéta and Balvan, Jan and Fojtů, Michaela and Binková, Hana and Horáková, Zuzana and Kostřica, Rom and Adam, Vojtech and Kizek, Rene and Masařík, Michal},
   article_location = {Dordrecht},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s13277-015-4569-6},
   keywords = {Head and neck cancer; Human papillomavirus; Tumor markers; Kaplan-Meier analysis},
   language = {eng},
   issn = {1010-4283},
   journal = {Tumor Biology},
   title = {Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC},
   volume = {37},
   year = {2016}
}

TY  - JOUR
ID  - 1356689
AU  - Polanská, Hana - Heger, Zbynek - Gumulec, Jaromír - Raudenská, Martina - Svobodová, Markéta - Balvan, Jan - Fojtů, Michaela - Binková, Hana - Horáková, Zuzana - Kostřica, Rom - Adam, Vojtech - Kizek, Rene - Masařík, Michal
PY  - 2016
TI  - Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC
JF  - Tumor Biology
VL  - 37
IS  - 6
SP  - 7193-7201
EP  - 7193-7201
PB  - Springer
SN  - 10104283
KW  - Head and neck cancer
KW  - Human papillomavirus
KW  - Tumor markers
KW  - Kaplan-Meier analysis
N2  - Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.
ER  -

POLANSKÁ, Hana, Zbynek HEGER, Jaromír GUMULEC, Martina RAUDENSKÁ, Markéta SVOBODOVÁ, Jan BALVAN, Michaela FOJTŮ, Hana BINKOVÁ, Zuzana HORÁKOVÁ, Rom KOSTŘICA, Vojtech ADAM, Rene KIZEK and Michal MASAŘÍK. Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC. \textit{Tumor Biology}. Dordrecht: Springer, 2016, vol.~37, No~6, p.~7193-7201. ISSN~1010-4283. Available from: https://dx.doi.org/10.1007/s13277-015-4569-6.

Detailed Information on Publication Record