Treponema pallidum, the syphilis spirochete: making a living as
a stealth pathogen

J 2016

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD et. al.

Základní údaje

Originální název

Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

Autoři

RADOLF, Justin D. (840 Spojené státy), Ranjit K. DEKA (840 Spojené státy), Arvind ANAND (840 Spojené státy), David ŠMAJS (203 Česká republika, garant, domácí), Michael V. NORGARD (840 Spojené státy) a X. Frank YANG (840 Spojené státy)

Vydání

Nature Reviews Microbiology, London, Nature Publishing Group, 2016, 1740-1526

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 26.819

Kód RIV

RIV/00216224:14110/16:00088237

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/nrmicro.2016.141

UT WoS

000388217400008

Klíčová slova anglicky

OUTER-MEMBRANE PROTEIN; PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE; LYME-DISEASE SPIROCHETE; WHOLE GENOME SEQUENCE; BORRELIA-BURGDORFERI; SECONDARY SYPHILIS; PHOSPHOTRANSFERASE SYSTEM; BINDING PROTEIN; SUBSP PALLIDUM; ANTIGENIC VARIATION

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 1. 2017 13:34, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation ‘the stealth pathogen’. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.

Návaznosti

GAP302/12/0574, projekt VaV

Název: Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema

Investor: Grantová agentura ČR, Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema

NT11159, projekt VaV

Název: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Investor: Ministerstvo zdravotnictví ČR, Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Citovat

RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD a X. Frank YANG. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. Nature Reviews Microbiology. London: Nature Publishing Group, 2016, roč. 14, č. 12, s. 744-759. ISSN 1740-1526. Dostupné z: https://dx.doi.org/10.1038/nrmicro.2016.141.

@article{1356791,
   author = {Radolf, Justin D. and Deka, Ranjit K. and Anand, Arvind and Šmajs, David and Norgard, Michael V. and Yang, X. Frank},
   article_location = {London},
   article_number = {12},
   doi = {http://dx.doi.org/10.1038/nrmicro.2016.141},
   keywords = {OUTER-MEMBRANE PROTEIN; PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE; LYME-DISEASE SPIROCHETE; WHOLE GENOME SEQUENCE; BORRELIA-BURGDORFERI; SECONDARY SYPHILIS; PHOSPHOTRANSFERASE SYSTEM; BINDING PROTEIN; SUBSP PALLIDUM; ANTIGENIC VARIATION},
   language = {eng},
   issn = {1740-1526},
   journal = {Nature Reviews Microbiology},
   title = {Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen},
   volume = {14},
   year = {2016}
}

TY  - JOUR
ID  - 1356791
AU  - Radolf, Justin D. - Deka, Ranjit K. - Anand, Arvind - Šmajs, David - Norgard, Michael V. - Yang, X. Frank
PY  - 2016
TI  - Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen
JF  - Nature Reviews Microbiology
VL  - 14
IS  - 12
SP  - 744-759
EP  - 744-759
PB  - Nature Publishing Group
SN  - 17401526
KW  - OUTER-MEMBRANE PROTEIN
KW  - PYROPHOSPHATE-DEPENDENT PHOSPHOFRUCTOKINASE
KW  - LYME-DISEASE SPIROCHETE
KW  - WHOLE GENOME SEQUENCE
KW  - BORRELIA-BURGDORFERI
KW  - SECONDARY SYPHILIS
KW  - PHOSPHOTRANSFERASE SYSTEM
KW  - BINDING PROTEIN
KW  - SUBSP PALLIDUM
KW  - ANTIGENIC VARIATION
N2  - The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation ‘the stealth pathogen’. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.
ER  -

RADOLF, Justin D., Ranjit K. DEKA, Arvind ANAND, David ŠMAJS, Michael V. NORGARD a X. Frank YANG. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. \textit{Nature Reviews Microbiology}. London: Nature Publishing Group, 2016, roč.~14, č.~12, s.~744-759. ISSN~1740-1526. Dostupné z: https://dx.doi.org/10.1038/nrmicro.2016.141.

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