RESSNEROVÁ, Alžběta, Martina RAUDENSKÁ, Monika HOLUBOVÁ, Markéta SVOBODOVÁ, Hana POLANSKÁ, Petr BABULA, Michal MASAŘÍK a Jaromír GUMULEC. Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis. Current Medicinal Chemistry. Sharjah: Betham Science Publishers, 2016, roč. 23, č. 13, s. 1304-1330. ISSN 0929-8673. Dostupné z: https://dx.doi.org/10.2174/0929867323666160405111543. |
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@article{1357221, author = {Ressnerová, Alžběta and Raudenská, Martina and Holubová, Monika and Svobodová, Markéta and Polanská, Hana and Babula, Petr and Masařík, Michal and Gumulec, Jaromír}, article_location = {Sharjah}, article_number = {13}, doi = {http://dx.doi.org/10.2174/0929867323666160405111543}, keywords = {zinc; copper; ceruloplasmin; metallothionein; cancer; head and neck tumour; metallomics; meta-analysis}, language = {eng}, issn = {0929-8673}, journal = {Current Medicinal Chemistry}, title = {Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis}, volume = {23}, year = {2016} }
TY - JOUR ID - 1357221 AU - Ressnerová, Alžběta - Raudenská, Martina - Holubová, Monika - Svobodová, Markéta - Polanská, Hana - Babula, Petr - Masařík, Michal - Gumulec, Jaromír PY - 2016 TI - Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis JF - Current Medicinal Chemistry VL - 23 IS - 13 SP - 1304-1330 EP - 1304-1330 PB - Betham Science Publishers SN - 09298673 KW - zinc KW - copper KW - ceruloplasmin KW - metallothionein KW - cancer KW - head and neck tumour KW - metallomics KW - meta-analysis N2 - Metals are known for playing essential roles in human physiology. Copper and zinc are trace elements closely dependent on one another and are involved in cell proliferation, growth, gene expression, apoptosis and other processes. Their homeostasis is crucial and tightly controlled by a resourceful system of transporters and transport proteins which deliver copper and zinc ions to their target sites. Abnormal zinc and copper homeostasis can be seen in a number of malignancies and also in head and neck cancer. Imbalance in this homeostasis is observed as an elevation or decrease of copper and zinc ions in serum or tissue levels in patients with cancer. In head and neck cancer these altered levels stand out from those of other malignancies which makes them an object of interest and therefore zinc and copper ions might be a good target for further research of head and neck cancer development and progression. This review aims to summarize the physiological roles of copper and zinc, its binding and transport mechanisms, and based on those, its role in head and neck cancer. To provide stronger evidence, dysregulation of levels is analysed by a meta-analytical approach. ER -
RESSNEROVÁ, Alžběta, Martina RAUDENSKÁ, Monika HOLUBOVÁ, Markéta SVOBODOVÁ, Hana POLANSKÁ, Petr BABULA, Michal MASAŘÍK a Jaromír GUMULEC. Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis. \textit{Current Medicinal Chemistry}. Sharjah: Betham Science Publishers, 2016, roč.~23, č.~13, s.~1304-1330. ISSN~0929-8673. Dostupné z: https://dx.doi.org/10.2174/0929867323666160405111543.
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