Impaired mitophagy in Fanconi anemia is dependent on
mitochondrial fission

J 2016

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission

SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA et. al.

Základní údaje

Originální název

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission

Autoři

SHYAMSUNDER, Pavithra (702 Singapur), Milan EŠNER (203 Česká republika, domácí), Maunish BARVALIA (356 Indie), Yu Jun WU (702 Singapur), Tomáš LOJA (703 Slovensko, domácí), Huat Bay BOON (702 Singapur), Matilde E. LLEONART (724 Španělsko), Rama S VERMA (356 Indie), Lumír KREJČÍ (203 Česká republika, garant, domácí) a Alex LYAKHOVICH (643 Rusko, domácí)

Vydání

Oncotarget, New York, Impact Journals, 2016, 1949-2553

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.168

Kód RIV

RIV/00216224:14110/16:00091248

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.18632/oncotarget.11161

UT WoS

000387153200048

Klíčová slova anglicky

mitophagy; impaired autophagy; Fanconi anemia; ROS; oxidative stress

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 1. 2017 14:30, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Fanconi anemia (FA) is a rare genetic disorder associated with bone-marrow failure, genome instability and cancer predisposition. Recently, we and others have demonstrated dysfunctional mitochondria with morphological alterations in FA cells accompanied by high reactive oxygen species (ROS) levels. Mitochondrial morphology is regulated by continuous fusion and fission events and the misbalance between these two is often accompanied by autophagy. Here, we provide evidence of impaired autophagy in FA. We demonstrate that FA cells have increased number of autophagic (presumably mitophagic) events and accumulate dysfunctional mitochondria due to an impaired ability to degrade them. Moreover, mitochondrial fission accompanied by oxidative stress (OS) is a prerequisite condition for mitophagy in FA and blocking this pathway may release autophagic machinery to clear dysfunctional mitochondria.

Přiložené soubory

EL_1357230.pdf

Požádat o autorskou verzi souboru

Citovat

SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA, Huat Bay BOON, Matilde E. LLEONART, Rama S VERMA, Lumír KREJČÍ a Alex LYAKHOVICH. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. Oncotarget. New York: Impact Journals, 2016, roč. 7, č. 36, s. 58065-58074. ISSN 1949-2553. Dostupné z: https://dx.doi.org/10.18632/oncotarget.11161.

@article{1357230,
   author = {Shyamsunder, Pavithra and Ešner, Milan and Barvalia, Maunish and Wu, Yu Jun and Loja, Tomáš and Boon, Huat Bay and Lleonart, Matilde E. and Verma, Rama S and Krejčí, Lumír and Lyakhovich, Alex},
   article_location = {New York},
   article_number = {36},
   doi = {http://dx.doi.org/10.18632/oncotarget.11161},
   keywords = {mitophagy; impaired autophagy; Fanconi anemia; ROS; oxidative stress},
   language = {eng},
   issn = {1949-2553},
   journal = {Oncotarget},
   title = {Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission},
   volume = {7},
   year = {2016}
}

TY  - JOUR
ID  - 1357230
AU  - Shyamsunder, Pavithra - Ešner, Milan - Barvalia, Maunish - Wu, Yu Jun - Loja, Tomáš - Boon, Huat Bay - Lleonart, Matilde E. - Verma, Rama S - Krejčí, Lumír - Lyakhovich, Alex
PY  - 2016
TI  - Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
JF  - Oncotarget
VL  - 7
IS  - 36
SP  - 58065-58074
EP  - 58065-58074
PB  - Impact Journals
SN  - 19492553
KW  - mitophagy
KW  - impaired autophagy
KW  - Fanconi anemia
KW  - ROS
KW  - oxidative stress
N2  - Fanconi anemia (FA) is a rare genetic disorder associated with bone-marrow failure, genome instability and cancer predisposition. Recently, we and others have demonstrated dysfunctional mitochondria with morphological alterations in FA cells accompanied by high reactive oxygen species (ROS) levels. Mitochondrial morphology is regulated by continuous fusion and fission events and the misbalance between these two is often accompanied by autophagy. Here, we provide evidence of impaired autophagy in FA. We demonstrate that FA cells have increased number of autophagic (presumably mitophagic) events and accumulate dysfunctional mitochondria due to an impaired ability to degrade them. Moreover, mitochondrial fission accompanied by oxidative stress (OS) is a prerequisite condition for mitophagy in FA and blocking this pathway may release autophagic machinery to clear dysfunctional mitochondria.
ER  -

SHYAMSUNDER, Pavithra, Milan EŠNER, Maunish BARVALIA, Yu Jun WU, Tomáš LOJA, Huat Bay BOON, Matilde E. LLEONART, Rama S VERMA, Lumír KREJČÍ a Alex LYAKHOVICH. Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission. \textit{Oncotarget}. New York: Impact Journals, 2016, roč.~7, č.~36, s.~58065-58074. ISSN~1949-2553. Dostupné z: https://dx.doi.org/10.18632/oncotarget.11161.

Podrobný výpis o publikaci