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@article{1357244, author = {Šebesta, Marek and Urulangodi, Madhusoodanan and Štefanovie, Barbora and Szakal, Barnabas and Pačesa, Martin and Lisby, Michael and Branzei, Dana and Krejčí, Lumír}, article_location = {Oxford}, article_number = {1}, doi = {http://dx.doi.org/10.1093/nar/gkw882}, keywords = {SACCHAROMYCES-CEREVISIAE MUS81-MMS4; STRUCTURE-SPECIFIC ENDONUCLEASE; STIMULATES FLAP ENDONUCLEASE-1; UBIQUITIN-LIKE MODIFIER; HOMOLOGOUS RECOMBINATION; REPLICATION FORKS; STALLED REPLICATION; BUDDING YEAST; HOLLIDAY JUNCTIONS; GENOME INTEGRITY}, language = {eng}, issn = {0305-1048}, journal = {Nucleic Acids Research}, title = {Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains}, volume = {45}, year = {2017} }
TY - JOUR ID - 1357244 AU - Šebesta, Marek - Urulangodi, Madhusoodanan - Štefanovie, Barbora - Szakal, Barnabas - Pačesa, Martin - Lisby, Michael - Branzei, Dana - Krejčí, Lumír PY - 2017 TI - Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains JF - Nucleic Acids Research VL - 45 IS - 1 SP - 215-230 EP - 215-230 PB - Oxford University Press SN - 03051048 KW - SACCHAROMYCES-CEREVISIAE MUS81-MMS4 KW - STRUCTURE-SPECIFIC ENDONUCLEASE KW - STIMULATES FLAP ENDONUCLEASE-1 KW - UBIQUITIN-LIKE MODIFIER KW - HOMOLOGOUS RECOMBINATION KW - REPLICATION FORKS KW - STALLED REPLICATION KW - BUDDING YEAST KW - HOLLIDAY JUNCTIONS KW - GENOME INTEGRITY N2 - Replication across damaged DNA templates is accompanied by transient formation of sister chromatid junctions (SCJs). Cells lacking Esc2, an adaptor protein containing no known enzymatic domains, are defective in the metabolism of these SCJs. However, how Esc2 is involved in the metabolism of SCJs remains elusive. Here we show interaction between Esc2 and a structure-specific endonuclease Mus81- Mms4 (the Mus81 complex), their involvement in the metabolism of SCJs, and the effects Esc2 has on the enzymatic activity of the Mus81 complex. We found that Esc2 specifically interacts with the Mus81 complex via its SUMO-like domains, stimulates enzymatic activity of the Mus81 complex in vitro, and is involved in the Mus81 complex-dependent resolution of SCJs in vivo. Collectively, our data point to the possibility that the involvement of Esc2 in the metabolism of SCJs is, in part, via modulation of the activity of the Mus81 complex. ER -
ŠEBESTA, Marek, Madhusoodanan URULANGODI, Barbora ŠTEFANOVIE, Barnabas SZAKAL, Martin PAČESA, Michael LISBY, Dana BRANZEI a Lumír KREJČÍ. Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains. \textit{Nucleic Acids Research}. Oxford: Oxford University Press, 2017, roč.~45, č.~1, s.~215-230. ISSN~0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkw882.
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