TENORA, Lukáš, Juraj GALETA, Eva ŘEZNÍČKOVÁ, Vladimír KRYŠTOF a Milan POTÁČEK. Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that inhibit ALK5 Kinase. The Journal of Organic Chemistry. American Chemical Society, 2016, roč. 81, č. 23, s. 11841-11856. ISSN 0022-3263. Dostupné z: https://dx.doi.org/10.1021/acs.joc.6b02230. |
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@article{1358648, author = {Tenora, Lukáš and Galeta, Juraj and Řezníčková, Eva and Kryštof, Vladimír and Potáček, Milan}, article_number = {23}, doi = {http://dx.doi.org/10.1021/acs.joc.6b02230}, keywords = {Cross-Coupling reactions; Pd catalysed; 4H-pyrrolo[1;2-b]pyrazoles; ALK5 Kinase inhibitors;}, language = {eng}, issn = {0022-3263}, journal = {The Journal of Organic Chemistry}, title = {Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that inhibit ALK5 Kinase}, url = {http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b02230}, volume = {81}, year = {2016} }
TY - JOUR ID - 1358648 AU - Tenora, Lukáš - Galeta, Juraj - Řezníčková, Eva - Kryštof, Vladimír - Potáček, Milan PY - 2016 TI - Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that inhibit ALK5 Kinase JF - The Journal of Organic Chemistry VL - 81 IS - 23 SP - 11841-11856 EP - 11841-11856 PB - American Chemical Society SN - 00223263 KW - Cross-Coupling reactions KW - Pd catalysed KW - 4H-pyrrolo[1;2-b]pyrazoles KW - ALK5 Kinase inhibitors; UR - http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b02230 L2 - http://pubs.acs.org/doi/abs/10.1021/acs.joc.6b02230 N2 - C-H activation of position 3 of a substituted pyrazole ring catalyzed by palladium(II) was straightforward and convenient for arylated or heteroarylated 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles. Moreover, we introduced simple protection of the nitrogen in the pyridin-2-yl directing group, which otherwise does not allow cross-coupling reaction, by transformation to the N-oxide. Selected final products were reasonably selective ALK5 kinase inhibitors. ER -
TENORA, Lukáš, Juraj GALETA, Eva ŘEZNÍČKOVÁ, Vladimír KRYŠTOF a Milan POTÁČEK. Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that inhibit ALK5 Kinase. \textit{The Journal of Organic Chemistry}. American Chemical Society, 2016, roč.~81, č.~23, s.~11841-11856. ISSN~0022-3263. Dostupné z: https://dx.doi.org/10.1021/acs.joc.6b02230.
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