ŠEVČÍK, Radek, Jakub VANĚK, Romana MICHALICOVÁ, Přemysl LUBAL, Petr HERMANN, I.C. SANTOS, I. SANTOS and M.P.C CAMPELLO. Formation and decomplexation kinetics of copper(II) complexes with cyclen derivatives having mixed carboxylate and phosphonate pendant arms. Dalton Transactions. Royal Society of Chemistry, vol. 45, No 32, p. 12723-12733. ISSN 1477-9226. doi:10.1039/c6dt01127f. 2016.
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Basic information
Original name Formation and decomplexation kinetics of copper(II) complexes with cyclen derivatives having mixed carboxylate and phosphonate pendant arms
Authors ŠEVČÍK, Radek (203 Czech Republic, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution), Romana MICHALICOVÁ (203 Czech Republic, belonging to the institution), Přemysl LUBAL (203 Czech Republic, guarantor, belonging to the institution), Petr HERMANN (203 Czech Republic), I.C. SANTOS (620 Portugal), I. SANTOS (620 Portugal) and M.P.C CAMPELLO (620 Portugal).
Edition Dalton Transactions, Royal Society of Chemistry, 2016, 1477-9226.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10402 Inorganic and nuclear chemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.029
RIV identification code RIV/00216224:14310/16:00088303
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1039/c6dt01127f
UT WoS 000381478500017
Keywords in English POSITRON EMISSION TOMOGRAPHY; METAL COMPLEXES; DISSOCIATION KINETICS; COPPER64 RADIOPHARMACEUTICALS; MEDICAL APPLICATIONS
Tags AKR, rivok
Changed by Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 6/4/2017 16:38.
Abstract
The kinetic properties of Cu(II) complexes of H4dota and its analogues with one (H5do3ap), two in the 1,7-position (trans-H6do2a2p), three (H7doa3p) and four (H8dotp) phosphonic acid pendant arms were investigated. Relative differences in the reactivity among the differently protonated species of the same ligand are successively decreased with the more phosphonic acid groups in the ligand. The faster complexation is probably caused by the higher ability of phosphonates to bind the metal ion and/or to assist in the transfer of protons from the ring amine groups to the bulk water. The acid-assisted decomplexation kinetics of the complexes was followed in highly acidic solutions ([H+] = 0.01-5 M) and at different temperatures (15-70 degrees C) to determine the activation parameters of the reaction. The kinetic inertness of the Cu(II) complexes follows the order: H4dota; H5do3ap; trans-H6do2a2p; H7doa3p; H8dotp. To obtain information on the influence of additional pendant arms, analogous data were obtained for trans-H2do2a. The ligand is less reactive than H4dota, but the kinetic inertness of its Cu(II) complex is similar to that of the H4dota complex. As it was considered that the published thermodynamics data on the Cu(II)-H8dotp system are probably incorrect, the system was re-investigated. It showed a very high stability for the [Cu(dotp)](6-) species and the easy formation of several Cu2L species in the presence of an excess of the metal ion. Also, the structure of the (H6doa3p)- anion in the solid state was determined. These experimental data demonstrate that the substitution of acetic acid pendant arms by methylphosphonic acid ones in H4dota-like ligands significantly decreases the kinetic inertness of the Cu(II) complexes.
Links
GA13-08336S, research and development projectName: Hybridní materiály založené na makrocyklických ligandech pro využití v medicíně
Investor: Czech Science Foundation
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/A/1500/2015, interní kód MUName: Vývoj metod a instrumentace pro analýzu biologicky významných látek 2016
Investor: Masaryk University, Category A
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