Effect of T-2 toxin-contaminated diet on common carp (Cyprinus
carpio L.)

J 2017

Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)

MATEJOVÁ, Iveta, Martin FALDYNA, Helena MODRÁ, Jana BLÁHOVÁ, Miroslava PALÍKOVÁ et. al.

Základní údaje

Originální název

Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)

Autoři

MATEJOVÁ, Iveta (203 Česká republika, garant), Martin FALDYNA (203 Česká republika), Helena MODRÁ (203 Česká republika), Jana BLÁHOVÁ (203 Česká republika), Miroslava PALÍKOVÁ (203 Česká republika), Zdenka MARKOVÁ (203 Česká republika), Aleš FRANC (203 Česká republika), Monika VICENOVÁ (203 Česká republika), Libor VOJTEK (203 Česká republika, domácí), Jana BARTOŇKOVÁ (203 Česká republika, domácí), Pavla SEOHONOVÁ (203 Česká republika), Martin HOSTOVSKÝ (203 Česká republika) a Zdeňka SVOBODOVÁ (203 Česká republika)

Vydání

Fish & shellfish immunology, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, 1050-4648

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.185

Kód RIV

RIV/00216224:14310/17:00095917

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.fsi.2016.11.032

UT WoS

000392770000050

Klíčová slova anglicky

Mycotoxin; Trichothecenes Fusarium; TBARS; Complement; Phagocytes

Štítky

AKR, NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 4. 2018 13:37, Ing. Nicole Zrilić

Anotace

V originále

The T-2 toxin, a fungal metabolite produced by Fusarium molds, occurs in a range of agriculture products. Reduced availability of fish meal has led to increasing use of cereals as a source of protein in commercial aquaculture feeds, which has increased the potential for mycotoxin contamination. The purpose of this study was to investigate toxicity of T-2 toxin intake in common carp (Cyprinus carpio L.) using haematological, biochemical and immunological parameters and oxidative stress indices. In a four-week feeding trial, fish were fed a commercial diet with 5.3 mg/kg T-2 toxin added. Ingestion of contaminated diet did not lead to mortality of fish, probably due to lower feed intake. On the other hand, it significantly affected haematological variables such as haematocrit, haemoglobin, red blood cell counts leading to anemia and white blood cell counts leading to leukopenia due to lymphopenia. Plasma glucose concentration and alanine amino transferase activity showed a significant increase while triglycerides concentration decreased. Activity of ceruloplasmin was significantly decreased in plasma. Further, liver glutathione Stransferase activity was significantly increased and catalase activity decreased, in parallel with a significant increase in caudal kidney catalase activity and a decrease in glutathione peroxidase activity. Finally, lipid peroxidation (detected as malondialdehyde) was significantly increased in the liver and caudal kidney. Changes in non-specific immune response and cytokine levels in head kidney indicated immune system sensitivity to T-2 toxin. Overall, the results demonstrate that this feed-borne mycotoxin is able to induce anaemia and oxidative stress and cause changes in the immune response of common carp.

Citovat

MATEJOVÁ, Iveta, Martin FALDYNA, Helena MODRÁ, Jana BLÁHOVÁ, Miroslava PALÍKOVÁ, Zdenka MARKOVÁ, Aleš FRANC, Monika VICENOVÁ, Libor VOJTEK, Jana BARTOŇKOVÁ, Pavla SEOHONOVÁ, Martin HOSTOVSKÝ a Zdeňka SVOBODOVÁ. Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.). Fish & shellfish immunology. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, roč. 60, January, s. 458-465. ISSN 1050-4648. Dostupné z: https://dx.doi.org/10.1016/j.fsi.2016.11.032.

@article{1360515,
   author = {Matejová, Iveta and Faldyna, Martin and Modrá, Helena and Bláhová, Jana and Palíková, Miroslava and Marková, Zdenka and Franc, Aleš and Vicenová, Monika and Vojtek, Libor and Bartoňková, Jana and Seohonová, Pavla and Hostovský, Martin and Svobodová, Zdeňka},
   article_location = {London},
   article_number = {January},
   doi = {http://dx.doi.org/10.1016/j.fsi.2016.11.032},
   keywords = {Mycotoxin; Trichothecenes Fusarium; TBARS; Complement; Phagocytes},
   language = {eng},
   issn = {1050-4648},
   journal = {Fish & shellfish immunology},
   title = {Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)},
   volume = {60},
   year = {2017}
}

TY  - JOUR
ID  - 1360515
AU  - Matejová, Iveta - Faldyna, Martin - Modrá, Helena - Bláhová, Jana - Palíková, Miroslava - Marková, Zdenka - Franc, Aleš - Vicenová, Monika - Vojtek, Libor - Bartoňková, Jana - Seohonová, Pavla - Hostovský, Martin - Svobodová, Zdeňka
PY  - 2017
TI  - Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)
JF  - Fish & shellfish immunology
VL  - 60
IS  - January
SP  - 458-465
EP  - 458-465
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10504648
KW  - Mycotoxin
KW  - Trichothecenes Fusarium
KW  - TBARS
KW  - Complement
KW  - Phagocytes
N2  - The T-2 toxin, a fungal metabolite produced by Fusarium molds, occurs in a range of agriculture products. Reduced availability of fish meal has led to increasing use of cereals as a source of protein in commercial aquaculture feeds, which has increased the potential for mycotoxin contamination. The purpose of this study was to investigate toxicity of T-2 toxin intake in common carp (Cyprinus carpio L.) using haematological, biochemical and immunological parameters and oxidative stress indices. In a four-week feeding trial, fish were fed a commercial diet with 5.3 mg/kg T-2 toxin added. Ingestion of contaminated diet did not lead to mortality of fish, probably due to lower feed intake. On the other hand, it significantly affected haematological variables such as haematocrit, haemoglobin, red blood cell counts leading to anemia and white blood cell counts leading to leukopenia due to lymphopenia. Plasma glucose concentration and alanine amino transferase activity showed a significant increase while triglycerides concentration decreased. Activity of ceruloplasmin was significantly decreased in plasma. Further, liver glutathione Stransferase activity was significantly increased and catalase activity decreased, in parallel with a significant increase in caudal kidney catalase activity and a decrease in glutathione peroxidase activity. Finally, lipid peroxidation (detected as malondialdehyde) was significantly increased in the liver and caudal kidney. Changes in non-specific immune response and cytokine levels in head kidney indicated immune system sensitivity to T-2 toxin. Overall, the results demonstrate that this feed-borne mycotoxin is able to induce anaemia and oxidative stress and cause changes in the immune response of common carp.
ER  -

MATEJOVÁ, Iveta, Martin FALDYNA, Helena MODRÁ, Jana BLÁHOVÁ, Miroslava PALÍKOVÁ, Zdenka MARKOVÁ, Aleš FRANC, Monika VICENOVÁ, Libor VOJTEK, Jana BARTOŇKOVÁ, Pavla SEOHONOVÁ, Martin HOSTOVSKÝ a Zdeňka SVOBODOVÁ. Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.). \textit{Fish \&{} shellfish immunology}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, roč.~60, January, s.~458-465. ISSN~1050-4648. Dostupné z: https://dx.doi.org/10.1016/j.fsi.2016.11.032.

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