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@article{1360515, author = {Matejová, Iveta and Faldyna, Martin and Modrá, Helena and Bláhová, Jana and Palíková, Miroslava and Marková, Zdenka and Franc, Aleš and Vicenová, Monika and Vojtek, Libor and Bartoňková, Jana and Seohonová, Pavla and Hostovský, Martin and Svobodová, Zdeňka}, article_location = {London}, article_number = {January}, doi = {http://dx.doi.org/10.1016/j.fsi.2016.11.032}, keywords = {Mycotoxin; Trichothecenes Fusarium; TBARS; Complement; Phagocytes}, language = {eng}, issn = {1050-4648}, journal = {Fish & shellfish immunology}, title = {Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.)}, volume = {60}, year = {2017} }
TY - JOUR ID - 1360515 AU - Matejová, Iveta - Faldyna, Martin - Modrá, Helena - Bláhová, Jana - Palíková, Miroslava - Marková, Zdenka - Franc, Aleš - Vicenová, Monika - Vojtek, Libor - Bartoňková, Jana - Seohonová, Pavla - Hostovský, Martin - Svobodová, Zdeňka PY - 2017 TI - Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.) JF - Fish & shellfish immunology VL - 60 IS - January SP - 458-465 EP - 458-465 PB - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD SN - 10504648 KW - Mycotoxin KW - Trichothecenes Fusarium KW - TBARS KW - Complement KW - Phagocytes N2 - The T-2 toxin, a fungal metabolite produced by Fusarium molds, occurs in a range of agriculture products. Reduced availability of fish meal has led to increasing use of cereals as a source of protein in commercial aquaculture feeds, which has increased the potential for mycotoxin contamination. The purpose of this study was to investigate toxicity of T-2 toxin intake in common carp (Cyprinus carpio L.) using haematological, biochemical and immunological parameters and oxidative stress indices. In a four-week feeding trial, fish were fed a commercial diet with 5.3 mg/kg T-2 toxin added. Ingestion of contaminated diet did not lead to mortality of fish, probably due to lower feed intake. On the other hand, it significantly affected haematological variables such as haematocrit, haemoglobin, red blood cell counts leading to anemia and white blood cell counts leading to leukopenia due to lymphopenia. Plasma glucose concentration and alanine amino transferase activity showed a significant increase while triglycerides concentration decreased. Activity of ceruloplasmin was significantly decreased in plasma. Further, liver glutathione Stransferase activity was significantly increased and catalase activity decreased, in parallel with a significant increase in caudal kidney catalase activity and a decrease in glutathione peroxidase activity. Finally, lipid peroxidation (detected as malondialdehyde) was significantly increased in the liver and caudal kidney. Changes in non-specific immune response and cytokine levels in head kidney indicated immune system sensitivity to T-2 toxin. Overall, the results demonstrate that this feed-borne mycotoxin is able to induce anaemia and oxidative stress and cause changes in the immune response of common carp. ER -
MATEJOVÁ, Iveta, Martin FALDYNA, Helena MODRÁ, Jana BLÁHOVÁ, Miroslava PALÍKOVÁ, Zdenka MARKOVÁ, Aleš FRANC, Monika VICENOVÁ, Libor VOJTEK, Jana BARTOŇKOVÁ, Pavla SEOHONOVÁ, Martin HOSTOVSKÝ a Zdeňka SVOBODOVÁ. Effect of T-2 toxin-contaminated diet on common carp (Cyprinus carpio L.). \textit{Fish \&{} shellfish immunology}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017, roč.~60, January, s.~458-465. ISSN~1050-4648. Dostupné z: https://dx.doi.org/10.1016/j.fsi.2016.11.032.
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