CenH3 evolution reflects meiotic symmetry as predicted by the
centromere drive model

J 2016

CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model

ZEDEK, František a Petr BUREŠ

Základní údaje

Originální název

CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model

Autoři

ZEDEK, František (203 Česká republika, domácí) a Petr BUREŠ (203 Česká republika, garant, domácí)

Vydání

Scientific Reports, LONDON, NATURE PUBLISHING GROUP, 2016, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.259

Kód RIV

RIV/00216224:14310/16:00088363

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/srep33308

UT WoS

000383188000001

Klíčová slova anglicky

centromere drive; centromere; chromosomes; meiotic drive; CenH3; CENP-A; chromosomal evolution; karyotype; meiotic symmetry; meiotic asymmetry; holokinetic chromosomes

Štítky

AKR

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 3. 2018 16:19, prof. RNDr. Petr Bureš, Ph.D.

Anotace

V originále

The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades with asymmetric meiosis compared to the clades with only symmetric meiosis. However, despite the impression one might get from the literature, this key prediction of the centromere drive model has not only never been confirmed, but it has never been tested, because all the previous studies dealt only with the presence or absence instead of the frequency of positive selection. To provide evidence for or against different frequencies of positively selected CenH3 in asymmetrics and symmetrics, we have inferred the selective pressures acting on CenH3 in seventeen eukaryotic clades, including plants, animals, fungi, ciliates and apicomplexa, using codon-substitution models, and compared the inferred frequencies between asymmetrics and symmetrics in a quantitative manner. We have found that CenH3 has been evolving adaptively much more frequently in clades with asymmetric meiosis compared with clades displaying only symmetric meiosis which confirms the prediction of centromere drive model. Our findings indicate that the evolution of asymmetric meiosis required CenH3 to evolve adaptively more often to counterbalance the negative consequences of centromere drive.

Návaznosti

GA13-29362S, projekt VaV

Název: Evoluce holocentrických chromosomů (Akronym: EvoHolo)

Investor: Grantová agentura ČR, Evoluce holocentrických chromosomů

Citovat

ZEDEK, František a Petr BUREŠ. CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model. Scientific Reports. LONDON: NATURE PUBLISHING GROUP, 2016, roč. 6, September, s. "nestrankovano", 6 s. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep33308.

@article{1361213,
   author = {Zedek, František and Bureš, Petr},
   article_location = {LONDON},
   article_number = {September},
   doi = {http://dx.doi.org/10.1038/srep33308},
   keywords = {centromere drive; centromere; chromosomes; meiotic drive; CenH3; CENP-A; chromosomal evolution; karyotype; meiotic symmetry; meiotic asymmetry; holokinetic chromosomes},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model},
   url = {http://www.nature.com/articles/srep33308},
   volume = {6},
   year = {2016}
}

TY  - JOUR
ID  - 1361213
AU  - Zedek, František - Bureš, Petr
PY  - 2016
TI  - CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model
JF  - Scientific Reports
VL  - 6
IS  - September
SP  - "nestrankovano"
EP  - "nestrankovano"
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - centromere drive
KW  - centromere
KW  - chromosomes
KW  - meiotic drive
KW  - CenH3
KW  - CENP-A
KW  - chromosomal evolution
KW  - karyotype
KW  - meiotic symmetry
KW  - meiotic asymmetry
KW  - holokinetic chromosomes
UR  - http://www.nature.com/articles/srep33308
N2  - The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades with asymmetric meiosis compared to the clades with only symmetric meiosis. However, despite the impression one might get from the literature, this key prediction of the centromere drive model has not only never been confirmed, but it has never been tested, because all the previous studies dealt only with the presence or absence instead of the frequency of positive selection. To provide evidence for or against different frequencies of positively selected CenH3 in asymmetrics and symmetrics, we have inferred the selective pressures acting on CenH3 in seventeen eukaryotic clades, including plants, animals, fungi, ciliates and apicomplexa, using codon-substitution models, and compared the inferred frequencies between asymmetrics and symmetrics in a quantitative manner. We have found that CenH3 has been evolving adaptively much more frequently in clades with asymmetric meiosis compared with clades displaying only symmetric meiosis which confirms the prediction of centromere drive model. Our findings indicate that the evolution of asymmetric meiosis required CenH3 to evolve adaptively more often to counterbalance the negative consequences of centromere drive.
ER  -

ZEDEK, František a Petr BUREŠ. CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model. \textit{Scientific Reports}. LONDON: NATURE PUBLISHING GROUP, 2016, roč.~6, September, s.~''nestrankovano'', 6 s. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/srep33308.

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