Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?

ŠTOURAČ, Petr. Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde? Current medical research and opinion. Oxon: Taylor & Francis, 2016, roč. 32, č. 12, s. 1983-1984. ISSN 0300-7995. Dostupné z: https://dx.doi.org/10.1080/03007995.2016.1226164.

Základní údaje

• Originální název: Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
• Název česky: Remifentanil v reálných klinických podmínkách: Podivuhodný příběh dr. Jekylla a Mr. Hydea?
• Název anglicky: Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
• Autoři: ŠTOURAČ, Petr.
• Vydání: Current medical research and opinion, Oxon, Taylor & Francis, 2016, 0300-7995.

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Článek v odborném periodiku
• Obor: 30000 3. Medical and Health Sciences
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 2.757
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1080/03007995.2016.1226164
• UT WoS: 000388960800010
• Klíčová slova česky: remifentanil; porodní analgezie: opioidy navozená hyperalgezie
• Klíčová slova anglicky: remifentnail; obstetric analgesia; opioid-induced hyperalgesia
• Štítky: EL OK
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.

Anotace anglicky

It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.