2016
Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
ŠTOURAČ, PetrBasic information
Original name
Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
Name in Czech
Remifentanil v reálných klinických podmínkách: Podivuhodný příběh dr. Jekylla a Mr. Hydea?
Name (in English)
Remifentanil in Real Clinical Conditions: Strange Case of Dr. Jekyll and Mr. Hyde?
Authors
Edition
Current medical research and opinion, Oxon, Taylor & Francis, 2016, 0300-7995
Other information
Language
Czech
Type of outcome
Article in a journal
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
is not subject to a state or trade secret
References:
Impact factor
Impact factor: 2.757
Organization unit
Faculty of Medicine
UT WoS
000388960800010
Keywords (in Czech)
remifentanil; porodní analgezie: opioidy navozená hyperalgezie
Keywords in English
remifentnail; obstetric analgesia; opioid-induced hyperalgesia
Tags
Tags
International impact, Reviewed
Changed: 27/1/2017 09:59, Ing. Mgr. Věra Pospíšilíková
In the original language
It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.
In English
It appears that, like Dr. Jekyll and Mr. Hyde in the famous story by Robert Louis Stevenson, remifentanil in real clinical settings has two faces. While it is undoubtedly a potent and well controllable opioid agonist with unique pharmacokinetics and wide clinical application, on the other hand, perhaps no other opioid is as much associated with opioid-induced hyperalgesia (OIH), that is, initial analgesic effects that are followed by increased sensitivity to pain/reduced pain thresholds. Given the methodological variability of published studies, there is a need for more research including the contribution of remifentanil induced hyperalgesia to chronic pain and the role of pharmacological modulation to reverse this process. But the real clinically preferred examples of remifentanil use imply that the adverse effects can be maintained under control and therefore remifentanil does not have to follow the tragic fate of Stevenson’s story in the future.