Prognostic Significance of Surfactant Protein A, Surfactant
Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor
3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary
Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive
Disease

J 2016

Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease

DOUBKOVÁ, Martina, Michal KARPISEK, Jiri MAZOCH, Jana SKŘIČKOVÁ, Michael DOUBEK et. al.

Základní údaje

Originální název

Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease

Autoři

DOUBKOVÁ, Martina (203 Česká republika, domácí), Michal KARPISEK (203 Česká republika), Jiri MAZOCH (203 Česká republika), Jana SKŘIČKOVÁ (203 Česká republika, garant, domácí) a Michael DOUBEK (203 Česká republika, domácí)

Vydání

Sarcoidosis Vasculitis and Diffuse Lung Diseases, Fidenza, Mattioli 1885, 2016, 1124-0490

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.575

Kód RIV

RIV/00216224:14110/16:00092064

Organizační jednotka

Lékařská fakulta

UT WoS

000393274000005

EID Scopus

2-s2.0-85015352761

Klíčová slova anglicky

surfactant protein A; surfactant protein D; Clara cell protein 16; SIOO protein; trefoil factor 3

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2017 11:54, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.006,); 5) serum SP-A with pulmonary functions impairment in IFF (P=0.011); 6) serum SP-D level was associated with HRCT interstitial score in IPF (P=0.0346); and 7) serum SP-A was associated with staging of COPD according to spirometry (P<0.001). Moreover, our analysis showed that some biomarker levels differed significantly among the diseases: 1) BALF SP-D level differed between sarcoidosis and IPF; 2) serum SP-A level differed among IPF, sarcoidosis, COPD and was also different from healthy controls; 3) serum S100A6, S100A11 levels differed among IPF, sarcoidosis, COPD from healthy controls 4) serum SP-D, CC16, TFF-3 levels distinguished IPF patients from healthy controls; and 5) serum CC16, TFF3, PSP94 distinguished COPD patients from healthy controls. Our study shows that some of selected biomarkers should have prognostic value in the analysed lung disorders. On the other hand, these biomarkers do not appear to be unequivocally suitable for differential diagnosis of these disorders.

Přiložené soubory

EL_1363003.pdf

Požádat o autorskou verzi souboru

Citovat

DOUBKOVÁ, Martina, Michal KARPISEK, Jiri MAZOCH, Jana SKŘIČKOVÁ a Michael DOUBEK. Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease. Sarcoidosis Vasculitis and Diffuse Lung Diseases. Fidenza: Mattioli 1885, 2016, roč. 33, č. 3, s. 224-234. ISSN 1124-0490.

@article{1363003,
   author = {Doubková, Martina and Karpisek, Michal and Mazoch, Jiri and Skřičková, Jana and Doubek, Michael},
   article_location = {Fidenza},
   article_number = {3},
   keywords = {surfactant protein A; surfactant protein D; Clara cell protein 16; SIOO protein; trefoil factor 3},
   language = {eng},
   issn = {1124-0490},
   journal = {Sarcoidosis Vasculitis and Diffuse Lung Diseases},
   title = {Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease},
   volume = {33},
   year = {2016}
}

TY  - JOUR
ID  - 1363003
AU  - Doubková, Martina - Karpisek, Michal - Mazoch, Jiri - Skřičková, Jana - Doubek, Michael
PY  - 2016
TI  - Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease
JF  - Sarcoidosis Vasculitis and Diffuse Lung Diseases
VL  - 33
IS  - 3
SP  - 224-234
EP  - 224-234
PB  - Mattioli 1885
SN  - 11240490
KW  - surfactant protein A
KW  - surfactant protein D
KW  - Clara cell protein 16
KW  - SIOO protein
KW  - trefoil factor 3
N2  - Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.006,); 5) serum SP-A with pulmonary functions impairment in IFF (P=0.011); 6) serum SP-D level was associated with HRCT interstitial score in IPF (P=0.0346); and 7) serum SP-A was associated with staging of COPD according to spirometry (P<0.001). Moreover, our analysis showed that some biomarker levels differed significantly among the diseases: 1) BALF SP-D level differed between sarcoidosis and IPF; 2) serum SP-A level differed among IPF, sarcoidosis, COPD and was also different from healthy controls; 3) serum S100A6, S100A11 levels differed among IPF, sarcoidosis, COPD from healthy controls 4) serum SP-D, CC16, TFF-3 levels distinguished IPF patients from healthy controls; and 5) serum CC16, TFF3, PSP94 distinguished COPD patients from healthy controls. Our study shows that some of selected biomarkers should have prognostic value in the analysed lung disorders. On the other hand, these biomarkers do not appear to be unequivocally suitable for differential diagnosis of these disorders.
ER  -

DOUBKOVÁ, Martina, Michal KARPISEK, Jiri MAZOCH, Jana SKŘIČKOVÁ a Michael DOUBEK. Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease. \textit{Sarcoidosis Vasculitis and Diffuse Lung Diseases}. Fidenza: Mattioli 1885, 2016, roč.~33, č.~3, s.~224-234. ISSN~1124-0490.

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