| KNAUF, Sascha, Jane RAPHAEL, Oriol MITJÀ, Inyasi A. V. LEJORA, Idrissa S. CHUMA, Emmanuel K. BATAMUZI, Julius D. KEYYU, Robert FYUMAGWA, Simone LÜERT, Charmie GODORNES, Hsi LIU, Christiane SCHWARZ, David ŠMAJS, Philippe GRANGE, Dietmar ZINNER, Christian ROOS and Sheila A. LUKEHART. Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem. EBioMedicine. Amsterdam: Elsevier Science BV, 2016, vol. 11, "neuvedeno", p. 85-90. ISSN 2352-3964. Available from: https://dx.doi.org/10.1016/j.ebiom.2016.07.033. |
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@article{1364094,
author = {Knauf, Sascha and Raphael, Jane and Mitjà, Oriol and Lejora, Inyasi A. V. and Chuma, Idrissa S. and Batamuzi, Emmanuel K. and Keyyu, Julius D. and Fyumagwa, Robert and Lüert, Simone and Godornes, Charmie and Liu, Hsi and Schwarz, Christiane and Šmajs, David and Grange, Philippe and Zinner, Dietmar and Roos, Christian and Lukehart, Sheila A.},
article_location = {Amsterdam},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.ebiom.2016.07.033},
keywords = {Treponema pallidum; Dipteria; Yaws; Nonhuman primates; Transmission},
language = {eng},
issn = {2352-3964},
journal = {EBioMedicine},
title = {Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem},
volume = {11},
year = {2016}
}
TY - JOUR
ID - 1364094
AU - Knauf, Sascha - Raphael, Jane - Mitjà, Oriol - Lejora, Inyasi A. V. - Chuma, Idrissa S. - Batamuzi, Emmanuel K. - Keyyu, Julius D. - Fyumagwa, Robert - Lüert, Simone - Godornes, Charmie - Liu, Hsi - Schwarz, Christiane - Šmajs, David - Grange, Philippe - Zinner, Dietmar - Roos, Christian - Lukehart, Sheila A.
PY - 2016
TI - Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem
JF - EBioMedicine
VL - 11
IS - "neuvedeno"
SP - 85-90
EP - 85-90
PB - Elsevier Science BV
SN - 23523964
KW - Treponema pallidum
KW - Dipteria
KW - Yaws
KW - Nonhuman primates
KW - Transmission
N2 - Background: Recently, the World Health Organization launched a campaign to eradicate the tropical disease yaws, caused by the bacterium Treponema pallidum subsp. pertenue; however, for decades researchers have questioned whether flies act as a vector for the pathogen that could facilitate transmission. Methods: A total of 207 fly specimens were trapped in areas of Africa in which T. pallidum-induced skin ulcerations are common in wild baboons; 88 flies from Tarangire National Park and 119 from Lake Manyara National Park in Tanzania were analyzed by PCR for the presence of T. pallidum DNA. Findings: We report that in the two study areas, T. pallidum DNA was found in 17-24% of wild-caught flies of the order Diptera. Treponemal DNA sequences obtained from many of the flies match sequences derived from nearby baboon T. pallidum strains, and one of the fly species with an especially high prevalence of T. pallidum DNA, Musca sorbens, has previously been shown to transmit yaws in an experimental setting. Interpretation: Our results raise the possibility that flies play a role in yaws transmission; further research is warranted, given how important understanding transmission is for the eradication of this disfiguring disease.
ER -
KNAUF, Sascha, Jane RAPHAEL, Oriol MITJÀ, Inyasi A. V. LEJORA, Idrissa S. CHUMA, Emmanuel K. BATAMUZI, Julius D. KEYYU, Robert FYUMAGWA, Simone LÜERT, Charmie GODORNES, Hsi LIU, Christiane SCHWARZ, David ŠMAJS, Philippe GRANGE, Dietmar ZINNER, Christian ROOS and Sheila A. LUKEHART. Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem. \textit{EBioMedicine}. Amsterdam: Elsevier Science BV, 2016, vol.~11, ''neuvedeno'', p.~85-90. ISSN~2352-3964. Available from: https://dx.doi.org/10.1016/j.ebiom.2016.07.033.
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