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@proceedings{1364875, author = {Sedlák, Vratislav and Kacer, Petr and Koblízek, Vladimír and Neumannová, katerina and Zatloukal, Jaromír and Plutinský, Marek and Jakubec, Lukáš and Vlcková, Štepánka}, booktitle = {ERS International Congress 2016}, doi = {http://dx.doi.org/10.1183/13993003.congress-2016.PA1849}, keywords = {oxidative stress}, language = {eng}, title = {Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project}, year = {2016} }
TY - CONF ID - 1364875 AU - Sedlák, Vratislav - Kacer, Petr - Koblízek, Vladimír - Neumannová, katerina - Zatloukal, Jaromír - Plutinský, Marek - Jakubec, Lukáš - Vlcková, Štepánka PY - 2016 TI - Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project KW - oxidative stress N2 - Chronic obstructive pulmonary disease (COPD) is linked to increased oxidative and nitrative stress (RNOS) in the airways and systemic circulation. RNOS causes damage of fosfolipids and proteins in cellular membrane including airway epithelium. Exhaled breath analysis (EBC) can reflex intensity of RNOS in COPD. We compared concentration of RNOS biomarkers and anti-inflammatory lipoxin A4 (LXA4) in EBC in COPD patients and healthy controls before and after incremental shuttle walk test (ISWT), actigraphy was used to follow average daily steps 1 week before ISWT. In 29 patents with severe COPD (age 62±1,7, FEV1 48,8 ± 15,6%) and 17 age matched healthy controls were during 1 day performed EBC collection, EBC samples were frozen and analyzed by mass spectrometry with liqid chromatography. After EBC sampling subjects underwent ISWT, and then again gave EBC. ER -
SEDLÁK, Vratislav, Petr KACER, Vladimír KOBLÍZEK, katerina NEUMANNOVÁ, Jaromír ZATLOUKAL, Marek PLUTINSKÝ, Lukáš JAKUBEC a Štepánka VLCKOVÁ. Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project. In \textit{ERS International Congress 2016}. 2016. ISSN~0903-1936. Dostupné z: https://dx.doi.org/10.1183/13993003.congress-2016.PA1849.
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