a 2016

Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

JÍŘÍK, Radovan, Torfin TAXT, Karel SOUČEK, Jiří KRATOCHVÍLA, Ondřej MACÍČEK et. al.

Basic information

Original name

Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

Authors

JÍŘÍK, Radovan, Torfin TAXT, Karel SOUČEK, Jiří KRATOCHVÍLA, Ondřej MACÍČEK, Eva DRAŽANOVÁ and Zenon STARČUK

Edition

2016

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Medicine

Keywords in English

pharmakokinetic model cancer mouse perfusion
Změněno: 26/4/2019 09:58, Soňa Böhmová

Abstract

V originále

In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models [1] are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability- surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.