Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI

JÍŘÍK, Radovan, Torfin TAXT, Karel SOUČEK, Jiří KRATOCHVÍLA, Ondřej MACÍČEK, Eva DRAŽANOVÁ and Zenon STARČUK. Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI. 2016.

Basic information

• Original name: Comparison of the ATH and 2CXM models using low- and high-molecular-weight contrast agents in DCE-MRI
• Authors: JÍŘÍK, Radovan, Torfin TAXT, Karel SOUČEK, Jiří KRATOCHVÍLA, Ondřej MACÍČEK, Eva DRAŽANOVÁ and Zenon STARČUK.
• Edition: 2016.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Faculty of Medicine
• Keywords in English: pharmakokinetic model cancer mouse perfusion

Abstract

In DCE-MRI, tissue contrast-agent (CA) concentration curves are modeled as a convolution of the arterial input function (AIF) and the impulse residue function (IRF). The 2CXM and ATH models [1] are the most widely used advanced IRF models that provide separate estimates of blood flow, Fb, and permeability- surface area product, PS, contrary to the commonly applied Tofts models. No consensus exists on which advanced pharmacokinetic model is better. Simulation-based and blind-deconvolution-based preclinical model comparisons are published. This contribution presents a new model-evaluation method based on high- and low-molecular weight (MW) contrast-agents administered within one examination. Some perfusion parameters are expected to be MW-independent (namely Fb and blood volume—vb), while PS should decrease with increasing MW.