Microenvironmental interactions between endothelial and
lymphoma cells: a role for the canonical WNT pathway in Hodgkin
lymphoma

J 2017

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma

LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F. et. al.

Základní údaje

Originální název

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma

Autoři

LINKE, F. (276 Německo), M. HARENBERG (276 Německo), M.M. NIETERT (276 Německo), S. ZAUNIG (276 Německo), von Bonin F. (276 Německo), A. ARLT (276 Německo), M. SZCZEPANOWSKI (276 Německo), HA WEICH (276 Německo), S. LUTZ (276 Německo), C. DULLIN (276 Německo), Pavlína JANOVSKÁ (203 Česká republika, domácí), Michaela KRAFČÍKOVÁ (203 Česká republika, domácí), Lukáš TRANTÍREK (203 Česká republika, domácí), Petra OVESNÁ (203 Česká republika, domácí), W. KLAPPER (276 Německo), T. BEISSBARTH (276 Německo), F. ALVES (276 Německo), Vítězslav BRYJA (203 Česká republika, domácí), L. TRÜMPER (276 Německo), J. WILTING (276 Německo) a Dieter KUBE (276 Německo, garant)

Vydání

Leukemia, London, Nature Publishing Group, 2017, 0887-6924

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.023

Kód RIV

RIV/00216224:14310/17:00095626

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/leu.2016.232

UT WoS

000394058800012

Klíčová slova anglicky

CHRONIC LYMPHOCYTIC-LEUKEMIA; CHEMOKINE RECEPTOR CCR7; FUNCTIONAL CD30 LIGAND; GROWTH-FACTOR; CONSTITUTIVE ACTIVATION; TUMOR; EXPRESSION; DISEASE; DISSEMINATION; VEGF

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 4. 2018 10:47, Ing. Nicole Zrilić

Anotace

V originále

The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell-cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment. The role of the interplay between cHL and ECs remains poorly understood. Here we identify canonical WNT pathway activity as important for the mutual interactions between cHL cells and ECs. We demonstrate that local canonical WNT signaling activates cHL cell chemotaxis toward ECs, adhesion to EC layers and cell invasion using not only the Wnt-inhibitor Dickkopf, tankyrases and casein kinase 1 inhibitors but also knockdown of the lymphocyte enhancer binding-factor 1 (LEF-1) and beta-catenin in cHL cells. Furthermore, LEF-1- and beta-catenin-regulated cHL secretome promoted EC migration, sprouting and vascular tube formation involving vascular endothelial growth factor A (VEGF-A). Importantly, high VEGFA expression is associated with a worse overall survival of cHL patients. These findings strongly support the concept that WNTs might function as a regulator of lymphoma dissemination by affecting cHL cell chemotaxis and promoting EC behavior and thus angiogenesis through paracrine interactions.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-29793A, projekt VaV

Název: Analýza Wnt/PCP jako nástroj pro lepší management chronické lymfocytární leukémie

Citovat

LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING a Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. London: Nature Publishing Group, 2017, roč. 31, č. 2, s. 361-372. ISSN 0887-6924. Dostupné z: https://dx.doi.org/10.1038/leu.2016.232.

@article{1365014,
   author = {Linke, F. and Harenberg, M. and Nietert, M.M. and Zaunig, S. and F., von Bonin and Arlt, A. and Szczepanowski, M. and Weich, HA and Lutz, S. and Dullin, C. and Janovská, Pavlína and Krafčíková, Michaela and Trantírek, Lukáš and Ovesná, Petra and Klapper, W. and Beissbarth, T. and Alves, F. and Bryja, Vítězslav and Trümper, L. and Wilting, J. and Kube, Dieter},
   article_location = {London},
   article_number = {2},
   doi = {http://dx.doi.org/10.1038/leu.2016.232},
   keywords = {CHRONIC LYMPHOCYTIC-LEUKEMIA; CHEMOKINE RECEPTOR CCR7; FUNCTIONAL CD30 LIGAND; GROWTH-FACTOR; CONSTITUTIVE ACTIVATION; TUMOR; EXPRESSION; DISEASE; DISSEMINATION; VEGF},
   language = {eng},
   issn = {0887-6924},
   journal = {Leukemia},
   title = {Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma},
   url = {https://www.nature.com/articles/leu2016232},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1365014
AU  - Linke, F. - Harenberg, M. - Nietert, M.M. - Zaunig, S. - F., von Bonin - Arlt, A. - Szczepanowski, M. - Weich, HA - Lutz, S. - Dullin, C. - Janovská, Pavlína - Krafčíková, Michaela - Trantírek, Lukáš - Ovesná, Petra - Klapper, W. - Beissbarth, T. - Alves, F. - Bryja, Vítězslav - Trümper, L. - Wilting, J. - Kube, Dieter
PY  - 2017
TI  - Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma
JF  - Leukemia
VL  - 31
IS  - 2
SP  - 361-372
EP  - 361-372
PB  - Nature Publishing Group
SN  - 08876924
KW  - CHRONIC LYMPHOCYTIC-LEUKEMIA
KW  - CHEMOKINE RECEPTOR CCR7
KW  - FUNCTIONAL CD30 LIGAND
KW  - GROWTH-FACTOR
KW  - CONSTITUTIVE ACTIVATION
KW  - TUMOR
KW  - EXPRESSION
KW  - DISEASE
KW  - DISSEMINATION
KW  - VEGF
UR  - https://www.nature.com/articles/leu2016232
L2  - https://www.nature.com/articles/leu2016232
N2  - The interaction between vascular endothelial cells (ECs) and cancer cells is of vital importance to understand tumor dissemination. A paradigmatic cancer to study cell-cell interactions is classical Hodgkin Lymphoma (cHL) owing to its complex microenvironment. The role of the interplay between cHL and ECs remains poorly understood. Here we identify canonical WNT pathway activity as important for the mutual interactions between cHL cells and ECs. We demonstrate that local canonical WNT signaling activates cHL cell chemotaxis toward ECs, adhesion to EC layers and cell invasion using not only the Wnt-inhibitor Dickkopf, tankyrases and casein kinase 1 inhibitors but also knockdown of the lymphocyte enhancer binding-factor 1 (LEF-1) and beta-catenin in cHL cells. Furthermore, LEF-1- and beta-catenin-regulated cHL secretome promoted EC migration, sprouting and vascular tube formation involving vascular endothelial growth factor A (VEGF-A). Importantly, high VEGFA expression is associated with a worse overall survival of cHL patients. These findings strongly support the concept that WNTs might function as a regulator of lymphoma dissemination by affecting cHL cell chemotaxis and promoting EC behavior and thus angiogenesis through paracrine interactions.
ER  -

LINKE, F., M. HARENBERG, M.M. NIETERT, S. ZAUNIG, von Bonin F., A. ARLT, M. SZCZEPANOWSKI, HA WEICH, S. LUTZ, C. DULLIN, Pavlína JANOVSKÁ, Michaela KRAFČÍKOVÁ, Lukáš TRANTÍREK, Petra OVESNÁ, W. KLAPPER, T. BEISSBARTH, F. ALVES, Vítězslav BRYJA, L. TRÜMPER, J. WILTING a Dieter KUBE. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. \textit{Leukemia}. London: Nature Publishing Group, 2017, roč.~31, č.~2, s.~361-372. ISSN~0887-6924. Dostupné z: https://dx.doi.org/10.1038/leu.2016.232.

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