Predictive Motor Timing and the Cerebellar Vermis in
Schizophrenia: An fMRI Study

J 2016

Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study

LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ et. al.

Základní údaje

Originální název

Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study

Autoři

LOŠÁK, Jan (203 Česká republika, garant, domácí), Jitka HÜTTLOVÁ (203 Česká republika, domácí), Petra LIPOVÁ (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Martin BAREŠ (203 Česká republika, domácí), Pavel FILIP (703 Slovensko, domácí), Jozef ŽÚBOR (703 Slovensko, domácí), Libor USTOHAL (203 Česká republika, domácí), Jiří VANÍČEK (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, domácí)

Vydání

Schizophrenia Bulletin, Oxford, Oxford University Press, 2016, 0586-7614

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 7.575

Kód RIV

RIV/00216224:14110/16:00088932

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1093/schbul/sbw065

UT WoS

000388029100026

Klíčová slova anglicky

predictive timing; cognitive dysmetria; schizophrenia; cerebellum; fMRI; dopamine

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 12. 2016 09:27, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.

Návaznosti

NV15-31063A, projekt VaV

Název: Buněčné markery vedoucí ke specifické léčbě "na míru" schizofrenním pacientům

Přiložené soubory

EL_1365208.pdf

Požádat o autorskou verzi souboru

Citovat

LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ, Pavel FILIP, Jozef ŽÚBOR, Libor USTOHAL, Jiří VANÍČEK a Tomáš KAŠPÁREK. Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. Schizophrenia Bulletin. Oxford: Oxford University Press, 2016, roč. 42, č. 6, s. 1517-1527. ISSN 0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbw065.

@article{1365208,
   author = {Lošák, Jan and Hüttlová, Jitka and Lipová, Petra and Mareček, Radek and Bareš, Martin and Filip, Pavel and Žúbor, Jozef and Ustohal, Libor and Vaníček, Jiří and Kašpárek, Tomáš},
   article_location = {Oxford},
   article_number = {6},
   doi = {http://dx.doi.org/10.1093/schbul/sbw065},
   keywords = {predictive timing; cognitive dysmetria; schizophrenia; cerebellum; fMRI; dopamine},
   language = {eng},
   issn = {0586-7614},
   journal = {Schizophrenia Bulletin},
   title = {Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study},
   volume = {42},
   year = {2016}
}

TY  - JOUR
ID  - 1365208
AU  - Lošák, Jan - Hüttlová, Jitka - Lipová, Petra - Mareček, Radek - Bareš, Martin - Filip, Pavel - Žúbor, Jozef - Ustohal, Libor - Vaníček, Jiří - Kašpárek, Tomáš
PY  - 2016
TI  - Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study
JF  - Schizophrenia Bulletin
VL  - 42
IS  - 6
SP  - 1517-1527
EP  - 1517-1527
PB  - Oxford University Press
SN  - 05867614
KW  - predictive timing
KW  - cognitive dysmetria
KW  - schizophrenia
KW  - cerebellum
KW  - fMRI
KW  - dopamine
N2  - Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.
ER  -

LOŠÁK, Jan, Jitka HÜTTLOVÁ, Petra LIPOVÁ, Radek MAREČEK, Martin BAREŠ, Pavel FILIP, Jozef ŽÚBOR, Libor USTOHAL, Jiří VANÍČEK a Tomáš KAŠPÁREK. Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. \textit{Schizophrenia Bulletin}. Oxford: Oxford University Press, 2016, roč.~42, č.~6, s.~1517-1527. ISSN~0586-7614. Dostupné z: https://dx.doi.org/10.1093/schbul/sbw065.

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