Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum
and BG in Predictive Motor Timing

J 2016

Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing

LUNGU, Ovidiu V., Martin BAREŠ, Tao LIU, Christopher M. GOMEZ, Ivica CECHOVA et. al.

Základní údaje

Originální název

Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing

Autoři

LUNGU, Ovidiu V. (840 Spojené státy), Martin BAREŠ (203 Česká republika, garant, domácí), Tao LIU (840 Spojené státy), Christopher M. GOMEZ (840 Spojené státy), Ivica CECHOVA (203 Česká republika) a James ASHE (840 Spojené státy)

Vydání

Journal of Cognitive Neuroscience, Cambridge, MIT Press Journals, 2016, 0898-929X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.108

Kód RIV

RIV/00216224:14110/16:00092401

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1162/jocn_a_00943

UT WoS

000377442500002

Klíčová slova anglicky

BASAL-GANGLIA; RESPONSE-INHIBITION; PARKINSONS-DISEASE; SENSORY PREDICTION; FUNCTIONAL MRI; NEURAL BASIS; TIME; FUTURE; CORTEX; ATAXIA

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 12. 2016 10:27, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

We previously demonstrated that predictive motor timing (i.e., timing requiring visuomotor coordination in anticipation of a future event, such as catching or batting a ball) is impaired in patients with spinocerebellar ataxia (SCA) types 6 and 8 relative to healthy controls. Specifically, SCA patients had difficulties postponing their motor response while estimating the target kinematics. This behavioral difference relied on the activation of both cerebellum and striatum in healthy controls, but not in cerebellar patients, despite both groups activating certain parts of cerebellum during the task. However, the role of these two key structures in the dynamic adaptation of the motor timing to target kinematic properties remained unexplored. In the current paper, we analyzed these data with the aim of characterizing the trial-by-trial changes in brain activation. We found that in healthy controls alone, and in comparison with SCA patients, the activation in bilateral striatum was exclusively associated with past successes and that in the left putamen, with maintaining a successful performance across successive trials. In healthy controls, relative to SCA patients, a larger network was involved in maintaining a successful trial-by-trial strategy; this included cerebellum and fronto-parieto-temporo-occipital regions that are typically part of attentional network and action monitoring. Cerebellum was also part of a network of regions activated when healthy participants postponed their motor response from one trial to the next; SCA patients showed reduced activation relative to healthy controls in both cerebellum and striatum in the same contrast. These findings support the idea that cerebellum and striatum play complementary roles in the trial-by-trial adaptation in predictive motor timing. In addition to expanding our knowledge of brain structures involved in time processing, our results have implications for the understanding of BG disorders, such as Parkinson disease where feedback processing or reward learning is affected.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Přiložené soubory

EL_1365419.pdf

Požádat o autorskou verzi souboru

Citovat

LUNGU, Ovidiu V., Martin BAREŠ, Tao LIU, Christopher M. GOMEZ, Ivica CECHOVA a James ASHE. Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing. Journal of Cognitive Neuroscience. Cambridge: MIT Press Journals, 2016, roč. 28, č. 7, s. 920-934. ISSN 0898-929X. Dostupné z: https://dx.doi.org/10.1162/jocn_a_00943.

@article{1365419,
   author = {Lungu, Ovidiu V. and Bareš, Martin and Liu, Tao and Gomez, Christopher M. and Cechova, Ivica and Ashe, James},
   article_location = {Cambridge},
   article_number = {7},
   doi = {http://dx.doi.org/10.1162/jocn_a_00943},
   keywords = {BASAL-GANGLIA; RESPONSE-INHIBITION; PARKINSONS-DISEASE; SENSORY PREDICTION; FUNCTIONAL MRI; NEURAL BASIS; TIME; FUTURE; CORTEX; ATAXIA},
   language = {eng},
   issn = {0898-929X},
   journal = {Journal of Cognitive Neuroscience},
   title = {Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing},
   volume = {28},
   year = {2016}
}

TY  - JOUR
ID  - 1365419
AU  - Lungu, Ovidiu V. - Bareš, Martin - Liu, Tao - Gomez, Christopher M. - Cechova, Ivica - Ashe, James
PY  - 2016
TI  - Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing
JF  - Journal of Cognitive Neuroscience
VL  - 28
IS  - 7
SP  - 920-934
EP  - 920-934
PB  - MIT Press Journals
SN  - 0898929X
KW  - BASAL-GANGLIA
KW  - RESPONSE-INHIBITION
KW  - PARKINSONS-DISEASE
KW  - SENSORY PREDICTION
KW  - FUNCTIONAL MRI
KW  - NEURAL BASIS
KW  - TIME
KW  - FUTURE
KW  - CORTEX
KW  - ATAXIA
N2  - We previously demonstrated that predictive motor timing (i.e., timing requiring visuomotor coordination in anticipation of a future event, such as catching or batting a ball) is impaired in patients with spinocerebellar ataxia (SCA) types 6 and 8 relative to healthy controls. Specifically, SCA patients had difficulties postponing their motor response while estimating the target kinematics. This behavioral difference relied on the activation of both cerebellum and striatum in healthy controls, but not in cerebellar patients, despite both groups activating certain parts of cerebellum during the task. However, the role of these two key structures in the dynamic adaptation of the motor timing to target kinematic properties remained unexplored. In the current paper, we analyzed these data with the aim of characterizing the trial-by-trial changes in brain activation. We found that in healthy controls alone, and in comparison with SCA patients, the activation in bilateral striatum was exclusively associated with past successes and that in the left putamen, with maintaining a successful performance across successive trials. In healthy controls, relative to SCA patients, a larger network was involved in maintaining a successful trial-by-trial strategy; this included cerebellum and fronto-parieto-temporo-occipital regions that are typically part of attentional network and action monitoring. Cerebellum was also part of a network of regions activated when healthy participants postponed their motor response from one trial to the next; SCA patients showed reduced activation relative to healthy controls in both cerebellum and striatum in the same contrast. These findings support the idea that cerebellum and striatum play complementary roles in the trial-by-trial adaptation in predictive motor timing. In addition to expanding our knowledge of brain structures involved in time processing, our results have implications for the understanding of BG disorders, such as Parkinson disease where feedback processing or reward learning is affected.
ER  -

LUNGU, Ovidiu V., Martin BAREŠ, Tao LIU, Christopher M. GOMEZ, Ivica CECHOVA a James ASHE. Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing. \textit{Journal of Cognitive Neuroscience}. Cambridge: MIT Press Journals, 2016, roč.~28, č.~7, s.~920-934. ISSN~0898-929X. Dostupné z: https://dx.doi.org/10.1162/jocn\_{}a\_{}00943.

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