Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing

LUNGU, Ovidiu V., Martin BAREŠ, Tao LIU, Christopher M. GOMEZ, Ivica CECHOVA a James ASHE. Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing. Journal of Cognitive Neuroscience. Cambridge: MIT Press Journals, 2016, roč. 28, č. 7, s. 920-934. ISSN 0898-929X. Dostupné z: https://dx.doi.org/10.1162/jocn_a_00943.

Základní údaje

• Originální název: Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing
• Autoři: LUNGU, Ovidiu V. (840 Spojené státy), Martin BAREŠ (203 Česká republika, garant, domácí), Tao LIU (840 Spojené státy), Christopher M. GOMEZ (840 Spojené státy), Ivica CECHOVA (203 Česká republika) a James ASHE (840 Spojené státy).
• Vydání: Journal of Cognitive Neuroscience, Cambridge, MIT Press Journals, 2016, 0898-929X.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30000 3. Medical and Health Sciences
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• Impakt faktor: Impact factor: 3.108
• Kód RIV: RIV/00216224:14110/16:00092401
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1162/jocn_a_00943
• UT WoS: 000377442500002
• Klíčová slova anglicky: BASAL-GANGLIA; RESPONSE-INHIBITION; PARKINSONS-DISEASE; SENSORY PREDICTION; FUNCTIONAL MRI; NEURAL BASIS; TIME; FUTURE; CORTEX; ATAXIA
• Štítky: EL OK, podil
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

We previously demonstrated that predictive motor timing (i.e., timing requiring visuomotor coordination in anticipation of a future event, such as catching or batting a ball) is impaired in patients with spinocerebellar ataxia (SCA) types 6 and 8 relative to healthy controls. Specifically, SCA patients had difficulties postponing their motor response while estimating the target kinematics. This behavioral difference relied on the activation of both cerebellum and striatum in healthy controls, but not in cerebellar patients, despite both groups activating certain parts of cerebellum during the task. However, the role of these two key structures in the dynamic adaptation of the motor timing to target kinematic properties remained unexplored. In the current paper, we analyzed these data with the aim of characterizing the trial-by-trial changes in brain activation. We found that in healthy controls alone, and in comparison with SCA patients, the activation in bilateral striatum was exclusively associated with past successes and that in the left putamen, with maintaining a successful performance across successive trials. In healthy controls, relative to SCA patients, a larger network was involved in maintaining a successful trial-by-trial strategy; this included cerebellum and fronto-parieto-temporo-occipital regions that are typically part of attentional network and action monitoring. Cerebellum was also part of a network of regions activated when healthy participants postponed their motor response from one trial to the next; SCA patients showed reduced activation relative to healthy controls in both cerebellum and striatum in the same contrast. These findings support the idea that cerebellum and striatum play complementary roles in the trial-by-trial adaptation in predictive motor timing. In addition to expanding our knowledge of brain structures involved in time processing, our results have implications for the understanding of BG disorders, such as Parkinson disease where feedback processing or reward learning is affected.

Návaznosti

• ED1.1.00/02.0068, projekt VaV: Název: CEITEC - central european institute of technology