Cerebellar Dysfunction and Ataxia in Patients with Epilepsy:
Coincidence, Consequence, or Cause?

J 2016

Cerebellar Dysfunction and Ataxia in Patients with Epilepsy: Coincidence, Consequence, or Cause?

MARCIÁN, Václav, Pavel FILIP, Martin BAREŠ and Milan BRÁZDIL

Basic information

Original name

Cerebellar Dysfunction and Ataxia in Patients with Epilepsy: Coincidence, Consequence, or Cause?

Authors

MARCIÁN, Václav (703 Slovakia, belonging to the institution), Pavel FILIP (203 Czech Republic), Martin BAREŠ (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution)

Edition

Tremor and Other Hyperkinetic Movements, New York, The Center for Digital Research and Scholarship, Columbia University Libraries / Information Services, 2016, 2160-8288

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/16:00092463

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.7916/D8KH0NBT

UT WoS

000443789200021

Keywords in English

Ataxia; epilepsy; seizures; atrophy; stimulation

Abstract

V originále

Basic epilepsy teachings assert that seizures arise from the cerebral cortex, glossing over infratentorial structures such as the cerebellum that are believed to modulate rather than generate seizures. Nonetheless, ataxia and other clinical findings in epileptic patients are slowly but inevitably drawing attention to this neural node. Tracing the evolution of this line of inquiry from the observed coincidence of cerebellar atrophy and cerebellar dysfunction (most apparently manifested as ataxia) in epilepsy to their close association, this review considers converging clinical, physiological, histological, and neuroimaging evidence that support incorporating the cerebellum into epilepsy pathology. We examine reports of still controversial cerebellar epilepsy, studies of cerebellar stimulation alleviating paroxysmal epileptic activity, studies and case reports of cerebellar lesions directly associated with seizures, and conditions in which ataxia is accompanied by epileptic seizures. Finally, the review substantiates the role of this complex brain structure in epilepsy whether by coincidence, as a consequence of deleterious cortical epileptic activity or antiepileptic drugs, or the very cause of the disease.

Citovat

MARCIÁN, Václav, Pavel FILIP, Martin BAREŠ and Milan BRÁZDIL. Cerebellar Dysfunction and Ataxia in Patients with Epilepsy: Coincidence, Consequence, or Cause? Tremor and Other Hyperkinetic Movements. New York: The Center for Digital Research and Scholarship, Columbia University Libraries / Information Services, 2016, vol. 2016, No 6, p. 1-12. ISSN 2160-8288. Available from: https://dx.doi.org/10.7916/D8KH0NBT.

@article{1365576,
   author = {Marcián, Václav and Filip, Pavel and Bareš, Martin and Brázdil, Milan},
   article_location = {New York},
   article_number = {6},
   doi = {http://dx.doi.org/10.7916/D8KH0NBT},
   keywords = {Ataxia; epilepsy; seizures; atrophy; stimulation},
   language = {eng},
   issn = {2160-8288},
   journal = {Tremor and Other Hyperkinetic Movements},
   title = {Cerebellar Dysfunction and Ataxia in Patients with Epilepsy: Coincidence, Consequence, or Cause?},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/27375960},
   volume = {2016},
   year = {2016}
}

TY  - JOUR
ID  - 1365576
AU  - Marcián, Václav - Filip, Pavel - Bareš, Martin - Brázdil, Milan
PY  - 2016
TI  - Cerebellar Dysfunction and Ataxia in Patients with Epilepsy: Coincidence, Consequence, or Cause?
JF  - Tremor and Other Hyperkinetic Movements
VL  - 2016
IS  - 6
SP  - 1-12
EP  - 1-12
PB  - The Center for Digital Research and Scholarship, Columbia University Libraries / Information Services
SN  - 21608288
KW  - Ataxia
KW  - epilepsy
KW  - seizures
KW  - atrophy
KW  - stimulation
UR  - https://www.ncbi.nlm.nih.gov/pubmed/27375960
L2  - https://www.ncbi.nlm.nih.gov/pubmed/27375960
N2  - Basic epilepsy teachings assert that seizures arise from the cerebral cortex, glossing over infratentorial structures such as the cerebellum that are believed to modulate rather than generate seizures. Nonetheless, ataxia and other clinical findings in epileptic patients are slowly but inevitably drawing attention to this neural node. Tracing the evolution of this line of inquiry from the observed coincidence of cerebellar atrophy and cerebellar dysfunction (most apparently manifested as ataxia) in epilepsy to their close association, this review considers converging clinical, physiological, histological, and neuroimaging evidence that support incorporating the cerebellum into epilepsy pathology. We examine reports of still controversial cerebellar epilepsy, studies of cerebellar stimulation alleviating paroxysmal epileptic activity, studies and case reports of cerebellar lesions directly associated with seizures, and conditions in which ataxia is accompanied by epileptic seizures. Finally, the review substantiates the role of this complex brain structure in epilepsy whether by coincidence, as a consequence of deleterious cortical epileptic activity or antiepileptic drugs, or the very cause of the disease.
ER  -

MARCIÁN, Václav, Pavel FILIP, Martin BAREŠ and Milan BRÁZDIL. Cerebellar Dysfunction and Ataxia in Patients with Epilepsy: Coincidence, Consequence, or Cause? \textit{Tremor and Other Hyperkinetic Movements}. New York: The Center for Digital Research and Scholarship, Columbia University Libraries / Information Services, 2016, vol.~2016, No~6, p.~1-12. ISSN~2160-8288. Available from: https://dx.doi.org/10.7916/D8KH0NBT.

Detailed Information on Publication Record