| ŘEMÍNEK, Roman, Lucie SLEZÁČKOVÁ, Jan SCHEJBAL a Zdeněk GLATZ. On-line capillary electrophoretic method for kinetic and inhibition studies of beta-secretase. Online. In František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník. CECE 2016. Brno: Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic, 2016, s. 227-229. ISBN 978-80-904959-4-4. |
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@inproceedings{1365958,
author = {Řemínek, Roman and Slezáčková, Lucie and Schejbal, Jan and Glatz, Zdeněk},
address = {Brno},
booktitle = {CECE 2016},
editor = {František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník},
keywords = {kinetics; enzyme; MALDI; BACE; mass spectrometry; inhibice},
howpublished = {elektronická verze "online"},
language = {eng},
location = {Brno},
isbn = {978-80-904959-4-4},
pages = {227-229},
publisher = {Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic},
title = {On-line capillary electrophoretic method for kinetic and inhibition studies of beta-secretase},
url = {http://www.ce-ce.org/CECE2016/Proceedings%20CECE%202016_WOS.pdf},
year = {2016}
}
TY - JOUR
ID - 1365958
AU - Řemínek, Roman - Slezáčková, Lucie - Schejbal, Jan - Glatz, Zdeněk
PY - 2016
TI - On-line capillary electrophoretic method for kinetic and inhibition studies of beta-secretase
PB - Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic
CY - Brno
SN - 9788090495944
KW - kinetics
KW - enzyme
KW - MALDI
KW - BACE
KW - mass spectrometry
KW - inhibice
UR - http://www.ce-ce.org/CECE2016/Proceedings%20CECE%202016_WOS.pdf
N2 - Alzheimer’s disease (AD) represents the most common cause of dementia. According to amyloid cascade hypothesis, pathogenesis of the disease could be slowed down or even stopped by inhibition of beta-secretase. On-line capillary electrophoretic methods represent a promising tool for screening of the enzyme’s activity. A generic on-line CE method for kinetic and inhibition studies of BACE was therefore introduced.
ER -
ŘEMÍNEK, Roman, Lucie SLEZÁČKOVÁ, Jan SCHEJBAL a Zdeněk GLATZ. On-line capillary electrophoretic method for kinetic and inhibition studies of beta-secretase. Online. In František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník. \textit{CECE 2016}. Brno: Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic, 2016, s.~227-229. ISBN~978-80-904959-4-4.
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