| SZADVÁRI, Ivan, Oľga KRIŽANOVÁ a Petr BABULA. Athymic Nude Mice as an Experimental Model for Cancer Treatment. Physiological Research. Praha: Fyziologický ústav AV ČR, 2016, roč. 65, Suppl. 4, s. "S441"-"S453", 13 s. ISSN 0862-8408. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1366116,
author = {Szadvári, Ivan and Križanová, Oľga and Babula, Petr},
article_location = {Praha},
article_number = {Suppl. 4},
keywords = {Athymic nude mice; Cancer; Experimental models; Anticancer treatment; Xenograft},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Athymic Nude Mice as an Experimental Model for Cancer Treatment},
volume = {65},
year = {2016}
}
TY - JOUR
ID - 1366116
AU - Szadvári, Ivan - Križanová, Oľga - Babula, Petr
PY - 2016
TI - Athymic Nude Mice as an Experimental Model for Cancer Treatment
JF - Physiological Research
VL - 65
IS - Suppl. 4
SP - "S441"-"S453"
EP - "S441"-"S453"
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Athymic nude mice
KW - Cancer
KW - Experimental models
KW - Anticancer treatment
KW - Xenograft
N2 - Athymic nude mice, a murine strain bearing spontaneous deletion in the Foxn1 gene that causes deteriorated or absent thymus (which results in inhibited immune system with reduction of number of T cells), represent a widely used model in cancer research having long lasting history as a tool for preclinical testing of drugs. The review describes three models of athymic mice that utilize cancer cell lines to induce tumors. In addition, various methods that can be applied in order to evaluate activity of anticancer agents in these models are shown and discussed. Although each model has certain disadvantages, they are still considered as inevitable instruments in many fields of cancer research, particularly in finding new drugs that would more effectively combat the cancer disease or enhance the use of current chemotherapy. Finally, the review summarizes strengths and weaknesses as well as future perspectives of the athymic nude mice model in cancer research.
ER -
SZADVÁRI, Ivan, Oľga KRIŽANOVÁ a Petr BABULA. Athymic Nude Mice as an Experimental Model for Cancer Treatment. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2016, roč.~65, Suppl. 4, s.~''S441''-''S453'', 13 s. ISSN~0862-8408.
|
