Non-Hodgkin lymphoma and pre-existing conditions: spectrum,
clinical characteristics and outcome in 213 children and
adolescents

J 2016

Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents

ATTARBASCHI, Andishe, Elisa CARRARO, Ousama ABLA, Shlomit BARZILAI-BIRENBOIM, Simon BOMKEN et. al.

Základní údaje

Originální název

Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents

Autoři

ATTARBASCHI, Andishe (40 Rakousko), Elisa CARRARO (380 Itálie), Ousama ABLA (124 Kanada), Shlomit BARZILAI-BIRENBOIM (376 Izrael), Simon BOMKEN (826 Velká Británie a Severní Irsko), Laurence BRUGIERES (250 Francie), Eva BUBANSKA (703 Slovensko), Birgit BURKHARDT (276 Německo), Alan k.S. CHIANG (344 Hongkong), Monika CSOKA (348 Maďarsko), Alina FEDOROVA (112 Bělorusko), Janez JAZBEC (705 Slovinsko), Edita KABICKOVA (203 Česká republika), Zdenka KŘENOVÁ (203 Česká republika, garant, domácí), Jelena LAZIC (688 Srbsko), Jan LOEFFEN (528 Nizozemské království), Georg MANN (40 Rakousko), Felix NIGGLI (756 Švýcarsko), Natalia MIAKOVA (643 Rusko), Tomoo OSUMI (392 Japonsko), Leila RONCERAY (40 Rakousko), Anne UYTTEBROECK (56 Belgie), Denise WILLIAMS (826 Velká Británie a Severní Irsko), Wilhelm WOESSMANN (276 Německo), Grazyna WROBEL (616 Polsko) a Marta PILLON (380 Itálie)

Vydání

Haematologica, Pavia, Ferrata Storti Foundation, 2016, 0390-6078

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 7.702

Kód RIV

RIV/00216224:14110/16:00092612

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3324/haematol.2016.147116

UT WoS

000392584400018

Klíčová slova anglicky

Non-Hodgkin lymphoma

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 4. 2017 13:46, Soňa Böhmová

Anotace

V originále

Children and adolescents with pre-existing conditions such as DNA repair defects or other primary immunodeficiencies have an increased risk of non-Hodgkin lymphoma. However, large-scale data on patients with non-Hodgkin lymphoma and their entire spectrum of pre-existing conditions are scarce. A retrospective multinational study was conducted by means of questionnaires sent out to the national study groups or centers, by the two largest consortia in childhood non-Hodgkin lymphoma, the European Intergroup for Childhood non-Hodgkin Lymphoma, and the international Berlin-Frankfurt-Münster Study Group. The study identified 213 patients with non-Hodgkin lymphoma and a pre-existing condition. Four subcategories were established: a) cancer predisposition syndromes (n=124, 58%); b) primary immunodeficiencies not further specified (n=27, 13%); c) genetic diseases with no increased cancer risk (n=40, 19%); and d) non-classifiable conditions (n=22, 10%). Seventy-nine of 124 (64%) cancer predispositions were reported in groups with more than 20 patients: ataxia telangiectasia (n=32), Nijmegen breakage syndrome (n=26), constitutional mismatch repair deficiency (n=21). For the 151 patients with a known cancer risk, 5-year event-free survival and overall survival rates were 40%±4% and 51%±4%, respectively. Five-year cumulative incidences of progression/relapse and treatment-related death as a first event were 22%±4% and 24%±4%, respectively. Ten-year incidence of second malignancy was 24%±5% and 7-year overall survival of the 21 patients with a second malignancy was 41%±11%. Patients with non-Hodgkin lymphoma and pre-existing conditions have an inferior survival rate with a large proportion of therapy-related deaths compared to patients with non-Hodgkin lymphoma and no pre-existing conditions. They may require special vigilance when receiving standard or modified/reduced-intensity chemotherapy or when undergoing allogeneic stem cell transplantation.

Citovat

ATTARBASCHI, Andishe, Elisa CARRARO, Ousama ABLA, Shlomit BARZILAI-BIRENBOIM, Simon BOMKEN, Laurence BRUGIERES, Eva BUBANSKA, Birgit BURKHARDT, Alan k.S. CHIANG, Monika CSOKA, Alina FEDOROVA, Janez JAZBEC, Edita KABICKOVA, Zdenka KŘENOVÁ, Jelena LAZIC, Jan LOEFFEN, Georg MANN, Felix NIGGLI, Natalia MIAKOVA, Tomoo OSUMI, Leila RONCERAY, Anne UYTTEBROECK, Denise WILLIAMS, Wilhelm WOESSMANN, Grazyna WROBEL a Marta PILLON. Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents. Haematologica. Pavia: Ferrata Storti Foundation, 2016, roč. 101, č. 12, s. 1581-1591. ISSN 0390-6078. Dostupné z: https://dx.doi.org/10.3324/haematol.2016.147116.

@article{1366347,
   author = {Attarbaschi, Andishe and Carraro, Elisa and Abla, Ousama and BarzilaiandBirenboim, Shlomit and Bomken, Simon and Brugieres, Laurence and Bubanska, Eva and Burkhardt, Birgit and Chiang, Alan k.S. and Csoka, Monika and Fedorova, Alina and Jazbec, Janez and Kabickova, Edita and Křenová, Zdenka and Lazic, Jelena and Loeffen, Jan and Mann, Georg and Niggli, Felix and Miakova, Natalia and Osumi, Tomoo and Ronceray, Leila and Uyttebroeck, Anne and Williams, Denise and Woessmann, Wilhelm and Wrobel, Grazyna and Pillon, Marta},
   article_location = {Pavia},
   article_number = {12},
   doi = {http://dx.doi.org/10.3324/haematol.2016.147116},
   keywords = {Non-Hodgkin lymphoma},
   language = {eng},
   issn = {0390-6078},
   journal = {Haematologica},
   title = {Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents},
   volume = {101},
   year = {2016}
}

TY  - JOUR
ID  - 1366347
AU  - Attarbaschi, Andishe - Carraro, Elisa - Abla, Ousama - Barzilai-Birenboim, Shlomit - Bomken, Simon - Brugieres, Laurence - Bubanska, Eva - Burkhardt, Birgit - Chiang, Alan k.S. - Csoka, Monika - Fedorova, Alina - Jazbec, Janez - Kabickova, Edita - Křenová, Zdenka - Lazic, Jelena - Loeffen, Jan - Mann, Georg - Niggli, Felix - Miakova, Natalia - Osumi, Tomoo - Ronceray, Leila - Uyttebroeck, Anne - Williams, Denise - Woessmann, Wilhelm - Wrobel, Grazyna - Pillon, Marta
PY  - 2016
TI  - Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents
JF  - Haematologica
VL  - 101
IS  - 12
SP  - 1581-1591
EP  - 1581-1591
PB  - Ferrata Storti Foundation
SN  - 03906078
KW  - Non-Hodgkin lymphoma
N2  - Children and adolescents with pre-existing conditions such as DNA repair defects or other primary immunodeficiencies have an increased risk of non-Hodgkin lymphoma. However, large-scale data on patients with non-Hodgkin lymphoma and their entire spectrum of pre-existing conditions are scarce. A retrospective multinational study was conducted by means of questionnaires sent out to the national study groups or centers, by the two largest consortia in childhood non-Hodgkin lymphoma, the European Intergroup for Childhood non-Hodgkin Lymphoma, and the international Berlin-Frankfurt-Münster Study Group. The study identified 213 patients with non-Hodgkin lymphoma and a pre-existing condition. Four subcategories were established: a) cancer predisposition syndromes (n=124, 58%); b) primary immunodeficiencies not further specified (n=27, 13%); c) genetic diseases with no increased cancer risk (n=40, 19%); and d) non-classifiable conditions (n=22, 10%). Seventy-nine of 124 (64%) cancer predispositions were reported in groups with more than 20 patients: ataxia telangiectasia (n=32), Nijmegen breakage syndrome (n=26), constitutional mismatch repair deficiency (n=21). For the 151 patients with a known cancer risk, 5-year event-free survival and overall survival rates were 40%±4% and 51%±4%, respectively. Five-year cumulative incidences of progression/relapse and treatment-related death as a first event were 22%±4% and 24%±4%, respectively. Ten-year incidence of second malignancy was 24%±5% and 7-year overall survival of the 21 patients with a second malignancy was 41%±11%. Patients with non-Hodgkin lymphoma and pre-existing conditions have an inferior survival rate with a large proportion of therapy-related deaths compared to patients with non-Hodgkin lymphoma and no pre-existing conditions. They may require special vigilance when receiving standard or modified/reduced-intensity chemotherapy or when undergoing allogeneic stem cell transplantation.
ER  -

ATTARBASCHI, Andishe, Elisa CARRARO, Ousama ABLA, Shlomit BARZILAI-BIRENBOIM, Simon BOMKEN, Laurence BRUGIERES, Eva BUBANSKA, Birgit BURKHARDT, Alan k.S. CHIANG, Monika CSOKA, Alina FEDOROVA, Janez JAZBEC, Edita KABICKOVA, Zdenka KŘENOVÁ, Jelena LAZIC, Jan LOEFFEN, Georg MANN, Felix NIGGLI, Natalia MIAKOVA, Tomoo OSUMI, Leila RONCERAY, Anne UYTTEBROECK, Denise WILLIAMS, Wilhelm WOESSMANN, Grazyna WROBEL a Marta PILLON. Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents. \textit{Haematologica}. Pavia: Ferrata Storti Foundation, 2016, roč.~101, č.~12, s.~1581-1591. ISSN~0390-6078. Dostupné z: https://dx.doi.org/10.3324/haematol.2016.147116.

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